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IPR005678

Description

IPR005678 is a Mitochondrial inner membrane translocase complex, subunit Tim17.

<p>The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. The inner membrane translocase is formed of a complex with a number of proteins, including the Tim17, Tim23 and Tim44 subunits. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane [[cite:PUB00014892]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Cellular component TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
Biological process Intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
Molecular function P-P-bond-hydrolysis-driven protein transmembrane transporter activity Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
PREDICTED: mitochondrial import inner membrane translocase subunit Tim17-like [Glycine max] gi|356495857|ref|XP_003516788.1| 6
PREDICTED: mitochondrial import inner membrane translocase subunit Tim17-like [Glycine max] gi|356575929|ref|XP_003556088.1| 9
PREDICTED: mitochondrial import inner membrane translocase subunit Tim17-like [Glycine max] gi|356575929|ref|XP_003556088.1| 4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33