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IPR005772

Source: InterPro

Description

IPR005772 is a ATPase, V1 complex, subunit F, eukaryotic.

<p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>V-ATPases (also known as V1V0-ATPase or vacuolar ATPase) are found in the eukaryotic endomembrane system, and in the plasma membrane of prokaryotes and certain specialised eukaryotic cells. V-ATPases hydrolyse ATP to drive a proton pump, and are involved in a variety of vital intra-and inter-cellular processes such as receptor mediated endocytosis, protein trafficking, active transport of metabolites, homeostasis and neurotransmitter release [[cite:PUB00020609]]. V-ATPases are composed of two linked complexes: the V1 complex (subunits A-H) contains the catalytic core that hydrolyses ATP, while the V0 complex (subunits a, c, c', c'', d) forms the membrane-spanning pore. V-ATPases may have an additional role in membrane fusion through binding to t-SNARE proteins [[cite:PUB00020608]].</p> <p>This entry represents subunit F found in the V1 complex of V-ATPases in eukaryotes. Subunit F is a 16kDa protein that is required for the assembly and activity of V-ATPase, and has a potential role in the differential targeting and regulation of the enzyme for specific organelles. This subunit is not necessary for the rotation of the ATPase V1 rotor, but it does promote catalysis [[cite:PUB00020639]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0033180
Cellular component Proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.
Subterm of
Part of
GO:0046961
Molecular function Proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.
Subterm of
GO:1902600
Biological process Proton transmembrane transport The directed movement of a proton across a membrane.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj1g3v4450310.1
– PREDICTED: V-type proton ATPase subunit F-like isoform 1 [Solanum lycopersicum] gi|460374930|ref|XP_004233261.1|
Domains
7
Lj4g3v0178660.1
– Uncharacterized protein isoform 3 [Theobroma cacao] gi|508709269|gb|EOY01166.1|
Domains
6
LotjaGi1g1v0714300.1
– V-type proton ATPase subunit F; TAIR: AT4G02620.1 vacuolar ATPase subunit F family protein; Swiss-Prot: sp|Q9ZQX4|VATF_ARATH V-type proton ATPase subunit F; TrEMBL-Plants: tr|I3T175|I3T175_LOTJA V-type proton ATPase subunit F; Found in the gene: LotjaGi1g1v0714300
Domains
10
LotjaGi1g1v0714300.2
– V-type proton ATPase subunit F; TAIR: AT4G02620.1 vacuolar ATPase subunit F family protein; Swiss-Prot: sp|Q9ZQX4|VATF_ARATH V-type proton ATPase subunit F; TrEMBL-Plants: tr|I3T175|I3T175_LOTJA V-type proton ATPase subunit F; Found in the gene: LotjaGi1g1v0714300
Domains
10
LotjaGi1g1v0714300.3
– V-type proton ATPase subunit F; TAIR: AT4G02620.1 vacuolar ATPase subunit F family protein; Swiss-Prot: sp|Q9ZQX4|VATF_ARATH V-type proton ATPase subunit F; TrEMBL-Plants: tr|I3T175|I3T175_LOTJA V-type proton ATPase subunit F; Found in the gene: LotjaGi1g1v0714300
Domains
10
LotjaGi4g1v0017700.2
– V-type proton ATPase subunit F; TAIR: AT4G02620.1 vacuolar ATPase subunit F family protein; Swiss-Prot: sp|Q9ZQX4|VATF_ARATH V-type proton ATPase subunit F; TrEMBL-Plants: tr|I3S5X5|I3S5X5_LOTJA V-type proton ATPase subunit F; Found in the gene: LotjaGi4g1v0017700
Domains
10
LotjaGi4g1v0017700.3
– V-type proton ATPase subunit F; TAIR: AT4G02620.1 vacuolar ATPase subunit F family protein; Swiss-Prot: sp|Q9ZQX4|VATF_ARATH V-type proton ATPase subunit F; TrEMBL-Plants: tr|I3S5X5|I3S5X5_LOTJA V-type proton ATPase subunit F; Found in the gene: LotjaGi4g1v0017700
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR01101 TIGRFAM 1 14.29