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IPR006287 is a Protein/nucleic acid deglycase DJ-1.
<p>Glycation is a nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was described in vitro as a protein deglycase that repaired methylglyoxal-and glyoxal-glycated proteins [[cite:PUB00079190], [cite:PUB00079193]]. Since then there have been reports against [[cite:PUB00084366]], and supporting this role for DJ-1 [[cite:PUB00084367]]. Furthermore, supporting its deglycase activity, DJ-1 and its bacterial homologues have been shown to be able to repair methylglyoxal-and glyoxal-glycated nucleotides and nucleic acids [[cite:PUB00086596]]. This ability would make DJ-1 a target for diabetic and cancer research [[cite:PUB00086597]]. DJ-1, also known as Park7, has been associated with human parkinsonism [[cite:PUB00079191]].</p> <p>Included in this family is also YajL from Escherichia coli, the bacterial homologue of DJ-1 [[cite:PUB00079194], [cite:PUB00079195]]. This group of proteins are classified as either DJ-1 putative peptidases or non-peptidase homologues in MEROPS peptidase family C56 (clan PC(C)).</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein DJ-1 homolog B-like [Cicer arietinum] gi|502089868|ref|XP_004489045.1| | 11 | ||
| – | Protein thiJ [Medicago truncatula] gi|357475343|ref|XP_003607957.1| | 17 | ||
| – | DJ-1 family protein; TAIR: AT1G53280.1 Class I glutamine amidotransferase-like superfamily protein; Swiss-Prot: sp|Q9MAH3|DJ1B_ARATH Protein DJ-1 homolog B; TrEMBL-Plants: tr|A0A072V987|A0A072V987_MEDTR Class I glutamine amidotransferase superfamily protein; Found in the gene: LotjaGi3g1v0157300 | 11 | ||
| – | Protein DJ-1; TAIR: AT4G34020.1 Class I glutamine amidotransferase-like superfamily protein; Swiss-Prot: sp|Q8VY09|DJ1C_ARATH Protein DJ-1 homolog C; TrEMBL-Plants: tr|I3SDB4|I3SDB4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0075100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |