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IPR007053 is a LRAT domain.
<p>This domain (LRAT domain) is found in a variety of proteins, including lecithin retinol acyltransferase (LRAT), HRAS-like suppressors (HRASLS1-5) and proteins FAM84A and FAM84B. Acyltransferase LRAT is the main enzyme that catalyzes vitamin A esterification [[cite:PUB00091723]]. HRASLS enzymes are also referred to as LRAT-like proteins because of their sequence homology to LRAT [[cite:PUB00061229]].</p> <p>The basic structural motif of the LRAT domain is composed of a four-strand antiparallel β-sheet and three α-helices. The longest α-helix (alpha3) is packed against the β-sheet, and the two other shorter α-helices are located on the sides. A highly conserved catalytic Cys, identified as the acylation site, is located near the N terminus of alpha3. This arrangement defines the active site location, which is embedded into a well defined groove formed by the extended loops between beta1-beta2, beta3-beta4, and the N terminus of the alpha3 helix. The side chain of the Cys is packed against a β-sheet core of the domain, placing it in close proximity to a conserved His from the beta2 strand. The β-sheet is spread open on one end allowing formation of a hydrogen bond between the His and the Cys. The third polar residue in this catalytic triad is a polar residue in the neighboring beta3 strand. The Cys residue was shown to act as a nucleophile and form a covalent thiol-acyl intermediate in the catalytic process [[cite:PUB00061229], [cite:PUB00065877], [cite:PUB00097553]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | NC domain-containing protein-related [Theobroma cacao] gi|508711177|gb|EOY03074.1| | 6 | ||
| – | Lecithin retinol acyltransferase domain protein [Arabidopsis thaliana] gi|18415178|ref|NP_568167.1| | 7 | ||
| – | NC domain-containing protein-related [Theobroma cacao] gi|508703754|gb|EOX95650.1| | 4 | ||
| – | NC domain-containing protein-related [Theobroma cacao] gi|508711177|gb|EOY03074.1| | 9 | ||
| – | NC domain-containing family protein; TAIR: AT3G02700.1 NC domain-containing protein-like protein; Swiss-Prot: sp|O95237|LRAT_HUMAN Lecithin retinol acyltransferase; TrEMBL-Plants: tr|I3SWC8|I3SWC8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0101800 | 8 | ||
| – | NC domain-containing protein-related; TAIR: AT1G01225.1 NC domain-containing protein-like protein; Swiss-Prot: sp|Q84J46|PP262_ARATH Pentatricopeptide repeat-containing protein At3g29290; TrEMBL-Plants: tr|A0A0S3S4S3|A0A0S3S4S3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0293300 | 4 | ||
| – | NC domain-containing protein-related; TAIR: AT1G01225.1 NC domain-containing protein-like protein; Swiss-Prot: sp|Q9JI61|LRAT_RAT Lecithin retinol acyltransferase; TrEMBL-Plants: tr|A0A0B2Q573|A0A0B2Q573_GLYSO Uncharacterized protein; Found in the gene: LotjaGi1g1v0794500 | 4 | ||
| – | NC domain-containing protein-related; TAIR: AT1G01225.1 NC domain-containing protein-like protein; Swiss-Prot: sp|Q9JI61|LRAT_RAT Lecithin retinol acyltransferase; TrEMBL-Plants: tr|A0A0S3S4S3|A0A0S3S4S3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0794500 | 4 | ||
| – | NC domain-containing protein; TAIR: AT5G06370.1 NC domain-containing protein-like protein; Swiss-Prot: sp|Q01IJ3|SUV3L_ORYSI ATP-dependent RNA helicase SUV3L, mitochondrial; TrEMBL-Plants: tr|A0A072VJG9|A0A072VJG9_MEDTR Lecithin retinol acyltransferase; Found in the gene: LotjaGi5g1v0105100 | 5 | ||
| – | NC domain-containing family protein; TAIR: AT3G02700.1 NC domain-containing protein-like protein; Swiss-Prot: sp|Q9JI60|LRAT_MOUSE Lecithin retinol acyltransferase; TrEMBL-Plants: tr|A0A151SZF4|A0A151SZF4_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0048900 | 3 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR46137 | PANTHER | 1 | 10.00 |