Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR007264 is a H/ACA ribonucleoprotein complex, subunit Nop10.
<p>H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes [[cite:PUB00053435]]. All H/ACA RNPs contain a specific RNA component (snoRNA or scaRNA) and at least four proteins common to all such particles: Cbf5, Gar1, Nhp2 and Nop10. These proteins are highly conserved from yeast to mammals and homologues are also present in archaea [[cite:PUB00088317]]. The H/ACA protein complex contains a stable core composed of Cbf5 and Nop10, to which Gar1 and Nhp2 subsequently bind [[cite:PUB00053436]].</p> <p>In eukaryotes Nop10 is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA snoRNAs (H/ACA snoRNPs). Nop10 is probably necessary for the stability of these RNPs [[cite:PUB00009858]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. | ||
| Molecular function | SnoRNA binding | Interacting selectively and non-covalently with small nucleolar RNA. | ||
| Biological process | Ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: H/ACA ribonucleoprotein complex subunit 3-like protein-like [Cucumis sativus] gi|449468560|ref|XP_004151989.1| | 7 | ||
| – | PREDICTED: H/ACA ribonucleoprotein complex subunit 3-like protein-like [Cucumis sativus] gi|449468560|ref|XP_004151989.1| | 7 | ||
| – | H/ACA ribonucleoprotein complex subunit 3-like protein; TAIR: AT2G20490.1 nucleolar RNA-binding Nop10p family protein; Swiss-Prot: sp|Q93XX8|NOP10_ARATH H/ACA ribonucleoprotein complex subunit 3-like protein; TrEMBL-Plants: tr|K7MYQ3|K7MYQ3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0707600_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF144210 | SUPERFAMILY | 1 | 33.33 |