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IPR007317

Source: InterPro

Description

IPR007317 is a Golgi to ER traffic protein 4.

<p>In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane [[cite:PUB00092561], [cite:PUB00092562]]. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation [[cite:PUB00092560], [cite:PUB00086005], [cite:PUB00086007], [cite:PUB00086008]]. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane [[cite:PUB00092560], [cite:PUB00086008], [cite:PUB00092563]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0045048
Biological process Protein insertion into ER membrane The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
Subterm of
Part of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj5g3v1853100.1
– PREDICTED: Golgi to ER traffic protein 4 homolog [Glycine max] gi|356576185|ref|XP_003556214.1|
Domains
5
Lj5g3v1853100.2
– PREDICTED: Golgi to ER traffic protein 4 homolog [Glycine max] gi|356576185|ref|XP_003556214.1|
Domains
5
LotjaGi5g1v0278200.1
– Golgi to ER traffic protein 4 like; TAIR: AT5G63220.1 golgi-to-ER traffic-like protein; Swiss-Prot: sp|Q54TH4|GET4_DICDI Golgi to ER traffic protein 4 homolog; TrEMBL-Plants: tr|I1NHC9|I1NHC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0278200
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
PTHR12875:SF1 PANTHER 1 33.33