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IPR007717 is a Nuclear pore localisation protein NPL4, C-terminal.
<p>The HRD4 gene is identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation following ubiquitination of target proteins but preceding their recognition by the 26S proteasome [[cite:PUB00010193]]. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing [[cite:PUB00019939]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: NPL4-like protein 1-like [Cicer arietinum] gi|502112372|ref|XP_004494310.1| | 15 | ||
| – | PREDICTED: NPL4-like protein 1-like [Cicer arietinum] gi|502112372|ref|XP_004494310.1| | 11 | ||
| – | NPL4 family protein; TAIR: AT2G47970.1 Nuclear pore localization protein NPL4; Swiss-Prot: sp|O82264|NPL42_ARATH NPL4-like protein 2; TrEMBL-Plants: tr|I1JQF4|I1JQF4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0743800 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd17055 | CDD | 1 | 33.33 |