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IPR007718 is a Srp40, C-terminal.
<p>This presumed domain is found at the C terminus of the budding yeast Srp40 and mammalian NOLC1 (also known as Nopp140) proteins. They are nucleolar proteins that contain a central domain consisting of ten repeats of acidic serine clusters alternating with lysine-, alanine- and proline-rich basic stretches [[cite:PUB00089268]]. Srp40 may be involved in preribosome assembly or transport [[cite:PUB00020370]]. Human NOLC1 interacts with casein kinase 2 (CK2), RNA polymerase I, p80 coilin , NAP57, and both major classes (box H/ACA and box C/D) of snoRNPs [[cite:PUB00089268]]. It acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification [[cite:PUB00089266], [cite:PUB00089267]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nucleolar and coiled-body phosphoprotein 1; TAIR: AT5G57120.1 nucleolar/coiled-body phosphoprotein; Swiss-Prot: sp|Q14978|NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1; TrEMBL-Plants: tr|A0A151SCL3|A0A151SCL3_CAJCA Nucleolar phosphoprotein p130 family; Found in the gene: LotjaGi4g1v0306900 | 8 | ||
| – | Nucleolar and coiled-body phosphoprotein 1; TAIR: AT5G57120.1 nucleolar/coiled-body phosphoprotein; Swiss-Prot: sp|Q14978|NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1; TrEMBL-Plants: tr|A0A151SCL3|A0A151SCL3_CAJCA Nucleolar phosphoprotein p130 family; Found in the gene: LotjaGi4g1v0306900 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |