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IPR007807 is a TcmA/NAT10, helicase domain.
<p>This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. It is found in NAT10 from eukaryotes and TmcA from prokaryotes. In NAT10, this domain catalyses the formation of N4-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs [[cite:PUB00076725], [cite:PUB00158942], [cite:PUB00158943]]. In TmcA, it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [[cite:PUB00050413]].</p> <p>The bacterial tRNA(Met) cytidine acetyltransferase (TmcA) catalyses the formation of N(4)-acetylcytidine (ac4C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and either ATP or GTP [[cite:PUB00056806]]. This modification is thought to ensure precise recognition of the AUG codon by strengthening C-G base-pair interaction and also prevent misrecognition of the near cognate AUA codon [[cite:PUB00050413]]. RNA cytidine acetyltransferas (NAT10) are RNA cytosine acetyltransferases with specificity toward both 18S rRNA and tRNAs and contain additional putative nuclear and nucleolar localisation signals (NLS and NoLS respectively) [[cite:PUB00076725], [cite:PUB00076726], [cite:PUB00107449]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: UPF0202 protein At1g10490-like [Cicer arietinum] gi|502139993|ref|XP_004504007.1| | 11 | ||
| – | RNA cytidine acetyltransferase; TAIR: AT1G10490.1 GNAT acetyltransferase (DUF699); Swiss-Prot: sp|Q9XIK4|NT101_ARATH RNA cytidine acetyltransferase 1; TrEMBL-Plants: tr|K7L6P0|K7L6P0_SOYBN RNA cytidine acetyltransferase; Found in the gene: LotjaGi4g1v0404200 | 19 | ||
| – | RNA cytidine acetyltransferase; TAIR: AT1G10490.1 GNAT acetyltransferase (DUF699); Swiss-Prot: sp|Q9XIK4|NT101_ARATH RNA cytidine acetyltransferase 1; TrEMBL-Plants: tr|A0A0B2RZ64|A0A0B2RZ64_GLYSO RNA cytidine acetyltransferase; Found in the gene: LotjaGi4g1v0404200 | 13 | ||
| – | RNA cytidine acetyltransferase; TAIR: AT1G10490.1 GNAT acetyltransferase (DUF699); Swiss-Prot: sp|Q9XIK4|NT101_ARATH RNA cytidine acetyltransferase 1; TrEMBL-Plants: tr|A0A0B2RZ64|A0A0B2RZ64_GLYSO RNA cytidine acetyltransferase; Found in the gene: LotjaGi4g1v0404200 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 25.00 |