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IPR033688

Source: InterPro

Description

IPR033688 is a RNA cytidine acetyltransferase NAT10.

<p>RNA cytidine acetyltransferase NAT10 has specificity toward both 18S rRNA and tRNAs and catalyzes the formation of N(4)-acetylcytidine at two positions in 18S rRNA. NAT10 is required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis [[cite:PUB00077545], [cite:PUB00076725]]. NAT10 also catalyzes the formation of N(4)-acetylcytidine at a single position in serine and leucine tRNAs. The tRNA-binding adapter protein TAN1 is required for full tRNA acetyltransferase activity but not for 18S rRNA acetylation [[cite:PUB00076725]].</p> <p>Human NAT10 is a lysine acetyltransferase that targets microtubules and histones, and plays an important role in cell division. It is highly expressed in malignant tumors [[cite:PUB00080263]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0008080
Molecular function N-acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
Subterm of
GO:0016072
Biological process RRNA metabolic process The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.
Subterm of
GO:0034470
Biological process NcRNA processing Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj4g3v2786840.1
– PREDICTED: UPF0202 protein At1g10490-like [Cicer arietinum] gi|502139993|ref|XP_004504007.1|
Domains
11
LotjaGi4g1v0404200.1
– RNA cytidine acetyltransferase; TAIR: AT1G10490.1 GNAT acetyltransferase (DUF699); Swiss-Prot: sp|Q9XIK4|NT101_ARATH RNA cytidine acetyltransferase 1; TrEMBL-Plants: tr|K7L6P0|K7L6P0_SOYBN RNA cytidine acetyltransferase; Found in the gene: LotjaGi4g1v0404200
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00