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IPR007846 is a RNA-recognition motif (RRM) Nup35-type domain.
<p>The nuclear pore complex (NPC) mediates the transport of macromolecules across the nuclear envelope (NE). The NPC is composed of a relatively small number of proteins (~30), termed nucleoporins or Nups. The vertebrate nuclear pore protein Nup35, the ortholog of Saccharomyces cerevisiae Nup53p, is suggested to interact with the NE membrane and to be required for nuclear morphology. The highly conserved region between vertebrate Nup35 and yeast Nup53p is predicted to contain an RNA-recognition motif (RRM) domain.</p> <p>The sequences of the RRM Nup-35-type domain are highly conserved in all eucaryotes. The RRM Nup35-type domain adopts the characteristic BetaAlphaBeta BetaAlphaBeta topology of the secondary structure elements, with a four- stranded antiparallel β-sheet packed against two α helices. The RRM Nup35-type domain forms a homodimer and contains atypical rinonucleoprotein (RNP) motifs, which lack the conserved residues that typically bind RNA in canonical RRM domains. The dimer interface involves the β-sheet surface, with its atypical RNP motifs, which is generally used to bind RNA in typical RRM domains [[cite:PUB00038167]].</p> <p>This entry represents the RRM Nup35-type domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nucleoporin NUP53-like [Cicer arietinum] gi|502081129|ref|XP_004486775.1| | 10 | ||
| – | Nuclear pore complex protein NUP35; TAIR: AT3G16310.1 mitotic phosphoprotein N' end (MPPN) family protein; Swiss-Prot: sp|O04326|NUP35_ARATH Nuclear pore complex protein NUP35; TrEMBL-Plants: tr|A0A0L9UP68|A0A0L9UP68_PHAAN Nuclear pore complex protein NUP35; Found in the gene: LotjaGi3g1v0020500 | 13 | ||
| – | Nuclear pore complex protein NUP35; TAIR: AT3G16310.1 mitotic phosphoprotein N' end (MPPN) family protein; Swiss-Prot: sp|O04326|NUP35_ARATH Nuclear pore complex protein NUP35; TrEMBL-Plants: tr|A0A0L9UP68|A0A0L9UP68_PHAAN Nuclear pore complex protein NUP35; Found in the gene: LotjaGi3g1v0020500 | 13 | ||
| – | Nuclear pore complex protein NUP35; TAIR: AT3G16310.1 mitotic phosphoprotein N' end (MPPN) family protein; Swiss-Prot: sp|O04326|NUP35_ARATH Nuclear pore complex protein NUP35; TrEMBL-Plants: tr|A0A0L9UP68|A0A0L9UP68_PHAAN Nuclear pore complex protein NUP35; Found in the gene: LotjaGi3g1v0020500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |