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IPR008591

Source: InterPro

Description

IPR008591 is a GINS complex subunit Sld5.

<p>GINS is a key component of eukaryotic replicative forks. It is part of the CMG (Cdc45-MCM-GINS) complex, the eukaryotic replicative helicase that unwinds double-stranded DNA at replication forks [[cite:PUB00085132]]. Beside its role as a key component of the CMG complex, GINS mediates a interactions with many replication factors [[cite:PUB00085133], [cite:PUB00085134]].</p> <p>GINS is composed of four subunits: Sld5, Psf1, Psf2, and Psf3 [[cite:PUB00085132]]. The four subunits are structurally related and are likely to derive from a single protein. They share a common fold made up of an α-helical A domain and a β-rich B domain. Sld5 and Psf1 possess the A domain at the N terminus and the B domain at the C terminus, whereas these two domains are swapped in Psf2 and Psf3 [[cite:PUB00085135]]. All subunits are essential for DNA replication.</p> <p>This family of proteins represents the Sld5 subunit.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006261
Biological process DNA-dependent DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0259149.1
– PREDICTED: DNA replication complex GINS protein SLD5-like isoform X1 [Cicer arietinum] gi|502086221|ref|XP_004488148.1|
Domains
9
LotjaGi3g1v0232500.1
– DNA replication complex GINS protein SLD5; TAIR: AT5G49010.1 DNA replication protein-like protein; Swiss-Prot: sp|Q99LZ3|SLD5_MOUSE DNA replication complex GINS protein SLD5; TrEMBL-Plants: tr|I3SQA1|I3SQA1_MEDTR DNA replication complex GINS protein SLD5; Found in the gene: LotjaGi3g1v0232500
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd11711 CDD 1 50.00