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IPR008969 is a Carboxypeptidase-like, regulatory domain superfamily.
<p>This domain superfamily identifies a number of eukaryotic carboxypeptidases, these include carboxypeptidase D, E (H), N, X, X2 and Z. These are metallopeptidases belong to MEROPS peptidase family M14 (clan MC), subfamily M14B.</p> <p>Carboxypeptidase D (CPD) is a new B-type metallocarboxypeptidase that is membrane bound and has an acidic pH optimum. A hydrophobic region at the N terminus represents the signal peptide, and one near the C terminus that probably represents the transmembrane anchor. A regulatory domain within the protein has been identified as a β-sandwich, comprising 7 strands in 2 sheets in a greek-key topology. Some family members have an additional 1-2 strands to the common fold [[cite:PUB00010644]].</p> <p>The bacterial and archaeal sequences having this signature are variously annotated, examples are:</p> <ul> <li>Hypothetical/conserved/membrane/cell surface protein</li> <li>N-acetylglucosamine deacetylase</li> <li>Side tail fibre protein homologue from lambdoid prophage Rac</li> <li>Hypothetical tonB-linked outer membrane receptor</li> <li>OmpA-related protein</li> <li>Putative outer membrane protein, probably involved in nutrient binding</li> <li>TonB-dependent receptor</li> </ul> <p>This entry also includes the teneurin family members, which may function as cellular signal transducers.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nodal modulator 1-like [Cicer arietinum] gi|502112755|ref|XP_004494433.1| | 21 | ||
| – | PREDICTED: carboxypeptidase D-like [Glycine max] gi|356534031|ref|XP_003535561.1| | 22 | ||
| – | Carbohydrate-binding-like fold protein; TAIR: AT3G62360.2 Carbohydrate-binding-like fold; Swiss-Prot: sp|Q6GQT9|NOMO1_MOUSE Nodal modulator 1; TrEMBL-Plants: tr|G7KTM5|G7KTM5_MEDTR Carbohydrate-binding-like fold protein; Found in the gene: LotjaGi1g1v0758800 | 20 | ||
| – | Carboxypeptidase; TAIR: AT1G71696.2 carboxypeptidase D; Swiss-Prot: sp|Q9M9H7|SOL1_ARATH Carboxypeptidase SOL1; TrEMBL-Plants: tr|I1NH52|I1NH52_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0287600 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18172 | CDD | 1 | 25.00 |