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IPR009011

Source: InterPro

Description

IPR009011 is a Mannose-6-phosphate receptor binding domain superfamily.

<p>Mannose-6-phosphate receptors (MPRs) are transmembrane proteins involved in the transport of lysosomal enzymes from the Golgi complex and the cell surface to lysosomes [[cite:PUB00002714]]. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to MPRs in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment, where the low pH mediates dissociation of the complex. There are two distinct MPRs that function in the recognition of mannose-6-phosphate-containing proteins: the cation-dependent MPR (CD-MPR) and the cation-independent MPR (CI-MPR). The CI-MPR is also known as the insulin-like growth factor II receptor, a multi-functional protein implicated in tumour suppression.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj4g3v0668360.1
– PREDICTED: glucosidase 2 subunit beta-like [Cicer arietinum] gi|502143453|ref|XP_004505348.1|
Domains
19
Lj6g3v1093300.1
– PREDICTED: protein OS-9-like isoform X1 [Cicer arietinum] gi|502087373|ref|XP_004488513.1|
Domains
14
LotjaGi4g1v0086600.1
– Glucosidase 2 subunit beta; TAIR: AT5G56360.1 calmodulin-binding protein; Swiss-Prot: sp|Q9FM96|PSL4_ARATH Glucosidase 2 subunit beta; TrEMBL-Plants: tr|A0A072UM12|A0A072UM12_MEDTR Glucosidase II beta subunit-like protein; Found in the gene: LotjaGi4g1v0086600
Domains
20
LotjaGi6g1v0209900.1
– Protein OS-9; TAIR: AT5G35080.1 ER lectin-like protein; Swiss-Prot: sp|Q8GWH3|OS9_ARATH Protein OS-9 homolog; TrEMBL-Plants: tr|A0A072V8G7|A0A072V8G7_MEDTR Glucosidase II beta subunit-like protein; Found in the gene: LotjaGi6g1v0209900
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TMhelix TMHMM 1 25.00