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IPR009210 is a Activating signal cointegrator 1 complex subunit 1.
<p>ASCC1, also called ASC-1 complex subunit p50, or Trip4 complex subunit p50, plays a role in DNA damage repair as component of the ASCC complex which consists of ASCC1, ASCC2 and ASCC3 subunits (p50, p100 and p200, respectively) [[cite:PUB00103503], [cite:PUB00090372]]. It is part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation [[cite:PUB00071532]]. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin [[cite:PUB00103507]]. ASCC1 may also play a role in the development of neuromuscular junction [[cite:PUB00103506]].</p> <p>This protein has an RNA-binding KH domain fused to a 2H RNA-phosphoesterase [[cite:PUB00103503], [cite:PUB00103506]] and modulates the ASCC3 helicase recruitment to the ASCC complex during alkylation damage.</p> <p>This entry also includes some uncharacterised proteins from fungi, such as the ASCC1 orthologue from S.pombe, C15D4.13c.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Activating signal cointegrator 1 complex subunit 1; TAIR: AT3G16230.12 Putative eukaryotic LigT; Swiss-Prot: sp|Q9D8Z1|ASCC1_MOUSE Activating signal cointegrator 1 complex subunit 1; TrEMBL-Plants: tr|I3RZY4|I3RZY4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0019900_LC | 5 | ||
| – | Activating signal cointegrator 1 complex subunit 1; TAIR: AT3G16230.12 Putative eukaryotic LigT; Swiss-Prot: sp|Q9D8Z1|ASCC1_MOUSE Activating signal cointegrator 1 complex subunit 1; TrEMBL-Plants: tr|I3RZY4|I3RZY4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0019900_LC | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR13360 | PANTHER | 1 | 50.00 |