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IPR019510 is a A-kinase anchor protein 7-like, phosphoesterase domain.
<p>This entry represents the phosphoesterase domain found in the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7 (also known as AKAP18). This domain belongs to the 2H RNA-phosphoesterase family and contains two conserved His-x-Thr motifs which, from structural studies, it has been suggested to bind AMP and CMP. It may act as a phosphoesterase, although its substrate has not been yet identified, or as an AMP sensor with the potential to couple intracellular AMP levels to PKA signalling events [[cite:PUB00103510], [cite:PUB00103512]]. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, through its C-terminal RI-RII subunit-binding domain [[cite:PUB00044142]]. AKAP7 also carries a nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein [[cite:PUB00044143]].</p> <p>The domain is also found in ASCC1 (activating signal cointegrator 1 complex subunit 1) [[cite:PUB00103506], [cite:PUB00103503]], referred to as the C-terminal RNA ligase-like domain closely related to that in AKAP7, and in leukocyte receptor cluster member 9 whose function is unclear. This domain lacks residues critical for ligase activity, and in ASCC1 plays an important role in the regulation of the ASCC complex localization upon alkylation damage [[cite:PUB00103503]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Activating signal cointegrator 1 complex subunit [Medicago truncatula] gi|357454839|ref|XP_003597700.1| | 15 | ||
| – | Activating signal cointegrator 1 complex subunit 1; TAIR: AT3G16230.12 Putative eukaryotic LigT; Swiss-Prot: sp|Q9D8Z1|ASCC1_MOUSE Activating signal cointegrator 1 complex subunit 1; TrEMBL-Plants: tr|I3RZY4|I3RZY4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0019900_LC | 5 | ||
| – | Activating signal cointegrator 1 complex subunit 1; TAIR: AT3G16230.12 Putative eukaryotic LigT; Swiss-Prot: sp|Q9D8Z1|ASCC1_MOUSE Activating signal cointegrator 1 complex subunit 1; TrEMBL-Plants: tr|I3RZY4|I3RZY4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0019900_LC | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR13360 | PANTHER | 1 | 33.33 |