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IPR009361 is a Centromere/kinetochore protein zw10, N-terminal.
<p>This domain is found N-terminal in homologues of Centromere/kinetochore protein ZW10.</p> <p>Zeste white 10 (ZW10) was initially identified as a mitotic checkpoint protein involved in chromosome segregation, and then implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, but it is also important in non-dividing cells. These include cytoplasmic dynein targeting to Golgi and other membranes, and SNARE-mediated ER-Golgi trafficking [[cite:PUB00044109], [cite:PUB00044110], [cite:PUB00100050]]. Dominant-negative ZW10, anti-ZW10 antibody, and ZW10 RNA interference (RNAi) cause Golgi dispersal. ZW10 RNAi also disperse endosomes and lysosomes [[cite:PUB00044110]].</p> <p>Drosophila kinetochore components Rough deal (Rod) and Zw10 are required for the proper functioning of the metaphase checkpoint in flies and mammals [[cite:PUB00100050], [cite:PUB00013411]]. The eukaryotic spindle assembly checkpoint (SAC) monitors microtubule attachment to kinetochores and prevents anaphase onset until all kinetochores are aligned on the metaphase plate. It is an essential surveillance mechanism that ensures high fidelity chromosome segregation during mitosis. In higher eukaryotes, cytoplasmic dynein is involved in silencing the SAC by removing the checkpoint proteins Mad2 and the Rod-Zw10-Zwilch complex (RZZ) from aligned kinetochores [[cite:PUB00044111], [cite:PUB00044112], [cite:PUB00044113]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. | ||
| Cellular component | Chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: centromere/kinetochore protein zw10 homolog [Cicer arietinum] gi|502097805|ref|XP_004491085.1| | 4 | ||
| – | Centromere/kinetochore protein zw10 like; TAIR: AT2G32900.1 centromere/kinetochore protein, putative (ZW10); Swiss-Prot: sp|O48626|ZW10_ARATH Centromere/kinetochore protein zw10 homolog; TrEMBL-Plants: tr|K7M513|K7M513_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0068400 | 5 | ||
| – | Centromere/kinetochore protein zw10 like; TAIR: AT2G32900.1 centromere/kinetochore protein, putative (ZW10); Swiss-Prot: sp|O48626|ZW10_ARATH Centromere/kinetochore protein zw10 homolog; TrEMBL-Plants: tr|K7KAZ4|K7KAZ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0068400 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR12205 | PANTHER | 1 | 33.33 |