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IPR009959 is a Polyketide cyclase SnoaL-like.
<p>Polyketides form a diverse group of compounds produced mainly by microorganisms and plants. This family of polyketide synthases includes aklanonic acid methyl ester cyclases, involved in the synthesis of aklavinone, an intermediate in the biosynthetic pathway of clinically important anthracyclines such as daunorubicin and doxorubicin [[cite:PUB00086899], [cite:PUB00086900]]. SnoaL belongs to this family; it is involved in nogalamycin biosynthesis [[cite:PUB00021066]].</p> <p>SnoaL adopts a distorted α-β barrel fold [[cite:PUB00021066]]. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation [[cite:PUB00021066]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Polyketide metabolic process | The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nuclear transport factor 2 family protein isoform 1 [Theobroma cacao] gi|508715446|gb|EOY07343.1| | 9 | ||
| – | Nuclear transport factor 2 (NTF2) family protein [Arabidopsis thaliana] gi|15217513|ref|NP_177304.1| | 7 | ||
| – | PREDICTED: F-box protein SKIP8-like [Glycine max] gi|356511437|ref|XP_003524433.1| | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 33.33 |