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IPR010014

Source: InterPro

Description

IPR010014 is a Diphthamide synthesis DHP2.

<p>DPH2, also known as diphthamide biosynthesis protein 2 or 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, has been shown in Saccharomyces cerevisiae (Baker's yeast) to be one of several required for the modification of a particular histidine residue of translation elongation factor 2 to diphthamide [[cite:PUB00005715]]. This modified site can then become the target for ADP-ribosylation by diphtheria toxin [[cite:PUB00017070]]. DPH proteins are highly conserved among eukaryotes [[cite:PUB00017070]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0017183
Biological process Peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj0g3v0235949.1
– PREDICTED: diphthamide biosynthesis protein 2-like [Cicer arietinum] gi|502124464|ref|XP_004498540.1|
Domains
8
Lj0g3v0235949.2
– PREDICTED: diphthamide biosynthesis protein 2-like [Cicer arietinum] gi|502124464|ref|XP_004498540.1|
Domains
11
Lj0g3v0235949.3
– PREDICTED: diphthamide biosynthesis protein 2-like [Cicer arietinum] gi|502124464|ref|XP_004498540.1|
Domains
11
Lj1g3v3531570.1
– PREDICTED: diphthamide biosynthesis protein 2-like [Cicer arietinum] gi|502124464|ref|XP_004498540.1|
Domains
12
Lj1g3v3531570.2
– PREDICTED: diphthamide biosynthesis protein 2-like [Cicer arietinum] gi|502124464|ref|XP_004498540.1|
Domains
12
Lj1g3v3531570.3
– PREDICTED: diphthamide biosynthesis protein 2-like [Cicer arietinum] gi|502124464|ref|XP_004498540.1|
Domains
9
Lj1g3v3531570.4
– PREDICTED: diphthamide biosynthesis protein 2-like [Cicer arietinum] gi|502124464|ref|XP_004498540.1|
Domains
11
LotjaGi1g1v0575100.1
– Diphthamide biosynthesis protein; TAIR: AT3G59630.1 diphthamide synthesis DPH2 family protein; Swiss-Prot: sp|A4QN59|DPH2_DANRE Diphthamide biosynthesis protein 2; TrEMBL-Plants: tr|A0A0S3SFB0|A0A0S3SFB0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0575100
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 12.50