Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR010137

Source: InterPro

Description

IPR010137 is a Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase.

<p>This entry describes LpxA, an enzyme for the biosynthesis of lipid A, a component of lipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species, but this protein represents the first step (from UDP-N-acetyl-D-glucosamine) and appears to be conserved in function [[cite:PUB00047894]]. Proteins from this family contain many copies of the bacterial transferase hexapeptide repeat [[cite:PUB00049010]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008610
Biological process Lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
Subterm of
GO:0008780
Molecular function Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj2g3v0911690.1
– PREDICTED: acyl-[acyl]-carrier-protein] gi|356523129|ref|XP_003530194.1|
Domains
12
LotjaGi2g1v0231800.1
– Acyl-[acyl]-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; TAIR: AT4G29540.2 bacterial transferase hexapeptide repeat-containing protein; Swiss-Prot: sp|Q9SU91|LPXA_ARATH Probable acyl-[acyl]-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A072UJ42|A0A072UJ42_MEDTR UDP-N-acetylglucosamine acyltransferase; Found in the gene: LotjaGi2g1v0231800
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03351 CDD 1 50.00