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IPR010198 is a 1,4-Dihydroxy-2-naphthoyl-CoA synthase, MenB.
<p>This entry represents an enzyme, naphthoate synthase [ec:4.1.3.36], MenB or dihydroxynaphthoic acid synthetase, which is involved in the fifth step of the menaquinone biosynthesis pathway. Menaquinone (vitamin K2), is an essential quinone used in electron-transfer pathways serving as the major electron carrier during anaerobic growth. In the bacterium, the biosynthetic pathway in bacteria typically comprises 6-7 steps [[cite:PUB00013809]]. Together with o-succinylbenzoate-CoA ligase (menE [interpro:IPR010192]), MenB takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoic acid (DHNA) [[cite:PUB00013809], [cite:PUB00030125], [cite:PUB00033363], [cite:PUB00033364]]. The conversion of o-succinylbenzoate-CoA ligase to DHNA is mediated by the enzyme DHNA synthase, which is encoded by menB [[cite:PUB00033365]].</p> <p>The protein structure of naphthoate synthase has been expressed in Escherichia coli, purified and crystallised, and found to have fold characteristics of the crotonase family of enzymes, which is notable for the presence of several highly flexible regions around the active site. The C-terminal region of the protein may play a critical role both in completion of the binding pocket and in stabilisation of the hexamer, suggesting a link between oligomerisation and catalytic activity [[cite:PUB00033366]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity | Catalysis of the reaction: 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-napthoyl-CoA + H2O. | ||
| Biological process | Menaquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 1,4-Dihydroxy-2-naphthoyl-CoA synthase, peroxisomal-like [Cicer arietinum] gi|502154602|ref|XP_004509757.1| | 16 | ||
| – | Fatty acid oxidation complex subunit alpha; TAIR: AT1G60550.1 enoyl-CoA hydratase/isomerase D; Swiss-Prot: sp|Q8GYN9|MENB_ARATH 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal; TrEMBL-Plants: tr|A0A072TT65|A0A072TT65_MEDTR 1,4-dihydroxy-2-naphthoyl-CoA synthase; Found in the gene: LotjaGi4g1v0167500 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06558 | CDD | 1 | 50.00 |