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IPR010286

Source: InterPro

Description

IPR010286 is a METTL16/RlmF family.

<p>This family includes ribosomal RNA large subunit methyltransferase F (RlmF), and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localisation [[cite:PUB00085149]]. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression [[cite:PUB00086421]].</p> <p>RlmF methylates the adenine in position 1618 of 23S rRNA [[cite:PUB00052324]]. This family also includes psilocybin synthase (PsiM), which is a methyltransferase involved in the biosynthesis of the psychotropic agent psilocybin from the mushroom Psilocybe cubensis [[cite:PUB00086873]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj4g3v0217740.1
– PREDICTED: methyltransferase-like protein 16 homolog [Cicer arietinum] gi|502141838|ref|XP_004504663.1|
Domains
10
LotjaGi4g1v0020500.1
– Methyltransferase-like protein; TAIR: AT2G21070.3 methyltransferase; Swiss-Prot: sp|Q6DC64|MET16_DANRE Methyltransferase-like protein 16; TrEMBL-Plants: tr|A0A0B2R5N2|A0A0B2R5N2_GLYSO Methyltransferase-like protein; Found in the gene: LotjaGi4g1v0020500
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00