Description

IPR010482 is a TECPR1-like, DysF domain.

<p>This entry represents the DysF domain found twice in human Tectonin beta-propeller repeat-containing protein 1 (TECPR1) and similar animal sequences. TECPR1 is a tethering factor involved in autophagy, autophagosome maturation and selective autophagy against bacterial pathogens [[cite:PUB00075565], [cite:PUB00094379]]. This protein has two 5-bladed β-propeller domains ([interpro:IPR006624]). The DysF domain lies inserted between the first and second blades of each propeller. It consists of a central pair of antiparallel β-strands connected via a long loop that wraps around the β-sheet and covers large parts of the elongated finger-shaped domain surface. The N-terminal DysF domain of TECPR1 detects and binds sphingomyelin [[cite:PUB00155245]].</p> <p>This domain is also found towards the N-terminal of Pex23 from Drosophila melanogaster, which shows structural similarity with Tectonin beta-propeller repeat-containing proteins but is involved in peroxisome biogenesis [[cite:PUB00155243]].</p> <p>Yeast peroxisomal proteins of the PEX28-32 family and at the N-terminal of Meiotically up-regulated gene 65 protein from Schizosaccharomyces pombe (Mug65) are also members of this group. PEX28/29 are involved in the regulation of peroxisome number, size and distribution [[cite:PUB00012364]]. Mug65 has a role in meiosis [[cite:PUB00044889]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: