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IPR026847 is a Vacuolar protein sorting-associated protein 13.
<p>Vacuolar protein sorting-associated protein 13 (VPS13) is involved in the delivery of proteins to the vacuole in vegetatively growing yeast [[cite:PUB00061935]] and also regulates membrane morphogenesis during sporulation [[cite:PUB00061936], [cite:PUB00100767]]. It mediates the transfer of lipids between membranes at organelle contact sites [[cite:PUB00100769], [cite:PUB00101953]] and it is involved in mitochondrial lipid homeostasis [[cite:PUB00100767], [cite:PUB00100726]]. In humans, the hereditary disorders chorea acanthocytosis and Cohen syndrome are caused by mutations in members of this family that are orthologues of yeast VPS13 (VPS13A and VPS13B respectively). Human VPS13A binds phospholipids and is required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria [[cite:PUB00100766], [cite:PUB00100726], [cite:PUB00061937]]. It is also required for efficient lysosomal protein degradation [[cite:PUB00100768]]. These proteins belong to the RNG superfamily (repeating β-grooves).</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Calcium-dependent lipid-binding family protein isoform 4 [Theobroma cacao] gi|508714946|gb|EOY06843.1| | 6 | ||
| – | Calcium-dependent lipid-binding family protein isoform 1 [Theobroma cacao] gi|508714943|gb|EOY06840.1| | 10 | ||
| – | Calcium-dependent lipid-binding family protein isoform 1 [Theobroma cacao] gi|508714943|gb|EOY06840.1| | 5 | ||
| – | Calcium-dependent lipid-binding family protein isoform 2, partial [Theobroma cacao] gi|508714944|gb|EOY06841.1| | 14 | ||
| – | Os08g0116700 [Oryza sativa Japonica Group] gi|115474517|ref|NP_001060855.1| | 6 | ||
| – | Calcium-dependent lipid-binding family protein isoform 3 [Theobroma cacao] gi|508714945|gb|EOY06842.1| | 3 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 5 | ||
| – | TonB box, N-terminal [Medicago truncatula] gi|124360289|gb|ABN08302.1| | 3 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 3 | ||
| – | C-5 cytosine-specific DNA methylase; Vacuolar protein sorting-associated protein [Medicago truncatula] gi|124360290|gb|ABN08303.1| | 8 | ||
| – | Vacuolar protein sorting-associated protein 13A [Medicago truncatula] gi|357482269|ref|XP_003611420.1| | 4 | ||
| – | Vacuolar protein sorting-associated protein 13A [Medicago truncatula] gi|357482269|ref|XP_003611420.1| | 7 | ||
| – | Vacuolar protein sorting-associated protein 13A [Medicago truncatula] gi|357482269|ref|XP_003611420.1| | 8 | ||
| – | Pleckstrin (PH) domain-containing protein isoform 2 [Theobroma cacao] gi|508776870|gb|EOY24126.1| | 24 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 8 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 5 | ||
| – | Os12g0594200 [Oryza sativa Japonica Group] gi|297613455|ref|NP_001067177.2| | 7 | ||
| – | Os12g0594200 [Oryza sativa Japonica Group] gi|297613455|ref|NP_001067177.2| | 5 | ||
| – | Os12g0594200 [Oryza sativa Japonica Group] gi|297613455|ref|NP_001067177.2| | 7 | ||
| – | Os12g0594200 [Oryza sativa Japonica Group] gi|297613455|ref|NP_001067177.2| | 7 | ||
| – | Vacuolar protein sorting-associated protein vps13 (exp=-1; wgp=0; cg=1, related [Medicago truncatula] gi|124360283|gb|ABN08296.1| | 6 | ||
| – | PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X4 [Cicer arietinum] gi|502170055|ref|XP_004514747.1| | 5 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 5 | ||
| – | Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357445545|ref|XP_003593050.1| | 3 | ||
| – | 5 | |||
| – | C-5 cytosine-specific DNA methylase; Vacuolar protein sorting-associated protein [Medicago truncatula] gi|124360290|gb|ABN08303.1| | 3 | ||
| – | 3 | |||
| – | C-5 cytosine-specific DNA methylase; Vacuolar protein sorting-associated protein [Medicago truncatula] gi|124360290|gb|ABN08303.1| | 5 | ||
| – | C-5 cytosine-specific DNA methylase; Vacuolar protein sorting-associated protein [Medicago truncatula] gi|124360290|gb|ABN08303.1| | 3 | ||
| – | C-5 cytosine-specific DNA methylase; Vacuolar protein sorting-associated protein [Medicago truncatula] gi|124360290|gb|ABN08303.1| | 3 | ||
| – | 3 | |||
| – | C-5 cytosine-specific DNA methylase; Vacuolar protein sorting-associated protein [Medicago truncatula] gi|124360290|gb|ABN08303.1| | 4 | ||
| – | Vacuolar protein sorting-associated protein 13A [Medicago truncatula] gi|357479115|ref|XP_003609843.1| | 5 | ||
| – | Calcium-dependent lipid-binding family protein isoform 2, partial [Theobroma cacao] gi|508714944|gb|EOY06841.1| | 14 | ||
| – | Calcium-dependent lipid-binding family protein isoform 1 [Theobroma cacao] gi|508714943|gb|EOY06840.1| | 7 | ||
| – | Vacuolar protein sorting-associated protein, putative; TAIR: AT5G24740.2 vacuolar protein sorting-associated protein, putative (DUF1162); Swiss-Prot: sp|Q54LB8|VP13A_DICDI Putative vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|G7IJW3|G7IJW3_MEDTR Vacuolar protein sorting-associated protein, putative; Found in the gene: LotjaGi1g1v0116300 | 15 | ||
| – | Pleckstrin (PH) domain-containing protein isoform 2; TAIR: AT4G17140.3 pleckstrin homology (PH) domain-containing protein; Swiss-Prot: sp|Q8BX70|VP13C_MOUSE Vacuolar protein sorting-associated protein 13C; TrEMBL-Plants: tr|G7JYP4|G7JYP4_MEDTR Vacuolar protein sorting protein; Found in the gene: LotjaGi2g1v0417400 | 24 | ||
| – | Vacuolar protein sorting-associated protein, putative (DUF1162); TAIR: AT3G50380.2 vacuolar protein sorting-associated protein, putative (DUF1162); Swiss-Prot: sp|Q55FG3|VP13C_DICDI Putative vacuolar protein sorting-associated protein 13C; TrEMBL-Plants: tr|K7MHD3|K7MHD3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0111200 | 9 | ||
| – | Vacuolar protein sorting-associated protein, putative; TAIR: AT5G24740.2 vacuolar protein sorting-associated protein, putative (DUF1162); Swiss-Prot: sp|Q54LB8|VP13A_DICDI Putative vacuolar protein sorting-associated protein 13A; TrEMBL-Plants: tr|G7IJW3|G7IJW3_MEDTR Vacuolar protein sorting-associated protein, putative; Found in the gene: LotjaGi4g1v0279000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 2.56 |