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IPR010561

Source: InterPro

Description

IPR010561 is a Protein LIN-9/Protein ALWAYS EARLY.

<p>This entry represents protein LIN-9/ALWAYS EARLY (LIN-9/ALY). LIN-9 from Caenorhabditis elegans is a homologue of the Drosophila always early (ALY) protein, which functions as a repressor of cell cycle regulated genes [[cite:PUB00067950], [cite:PUB00067944]].</p> <p>LIN-9 is a component of the evolutionary conserved DREAM (MuvB/DRM) complex, which represses transcription [[cite:PUB00067939]]. DREAM complex undergoes a cell cycle dependent switch of subunits. DREAM core binds to the E2F4 transcription factor and to the RBL2 (p130) in quiescent cells, while associates with the transcription factor B-MYB in the S-phase [[cite:PUB00067950]]. In humans, LIN-9 acts as a tumor suppressor and plays a role in the expression of genes required for the G1/S transition [[cite:PUB00067941], [cite:PUB00067942]]. In pluripotent embryonic stem cells (ESC), LIN-9 plays an important role for proliferation and genome stability by activating genes with important functions in mitosis and cytokinesis [[cite:PUB00067950]].</p> <p>In Arabidopsis thaliana, ALY is expressed ubiquitously in vegetative and reproductive tissues [[cite:PUB00067943]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006351
Biological process Transcription, DNA-templated The cellular synthesis of RNA on a template of DNA.
Subterm of
Part of
GO:0017053
Cellular component Transcriptional repressor complex A protein complex that possesses activity that prevents or downregulates transcription.
Subterm of

Associated Lotus transcripts 14

Transcript Name Description Predicted domains Domain count
Lj0g3v0057319.1
– Lin-9-like protein [Medicago truncatula] gi|357441687|ref|XP_003591121.1|
Domains
13
Lj0g3v0057329.1
– PREDICTED: protein ALWAYS EARLY 2-like [Glycine max] gi|356533577|ref|XP_003535339.1|
Domains
8
Lj0g3v0057329.2
– PREDICTED: protein ALWAYS EARLY 2-like [Glycine max] gi|356533577|ref|XP_003535339.1|
Domains
8
Lj0g3v0237869.1
– PREDICTED: protein ALWAYS EARLY 3-like isoform X1 [Cicer arietinum] gi|502151117|ref|XP_004508286.1|
Domains
4
Lj1g3v1077740.1
– PREDICTED: protein ALWAYS EARLY 2-like [Glycine max] gi|356533577|ref|XP_003535339.1|
Domains
3
Lj4g3v2367360.1
– PREDICTED: protein ALWAYS EARLY 3-like [Glycine max] gi|356563900|ref|XP_003550195.1|
Domains
15
LotjaGi1g1v0772500.1
– Always EARLY-like protein; TAIR: AT3G21430.3 DNA binding protein; Swiss-Prot: sp|Q6A332|ALY3_ARATH Protein ALWAYS EARLY 3; TrEMBL-Plants: tr|A0A0B2Q7U7|A0A0B2Q7U7_GLYSO Protein ALWAYS EARLY 3; Found in the gene: LotjaGi1g1v0772500
Domains
18
LotjaGi1g1v0772500.2
– Always EARLY-like protein; TAIR: AT3G05380.2 ALWAYS EARLY 2; Swiss-Prot: sp|Q6A333|ALY2_ARATH Protein ALWAYS EARLY 2; TrEMBL-Plants: tr|K7LJK4|K7LJK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0772500
Domains
18
LotjaGi1g1v0772500.3
– Always EARLY-like protein; TAIR: AT3G21430.3 DNA binding protein; Swiss-Prot: sp|Q6A332|ALY3_ARATH Protein ALWAYS EARLY 3; TrEMBL-Plants: tr|K7LJK4|K7LJK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0772500
Domains
18
LotjaGi1g1v0772500.4
– Always EARLY-like protein; TAIR: AT3G21430.3 DNA binding protein; Swiss-Prot: sp|Q6A332|ALY3_ARATH Protein ALWAYS EARLY 3; TrEMBL-Plants: tr|K7LJK4|K7LJK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0772500
Domains
18
LotjaGi4g1v0344700.1
– Always EARLY-like protein; TAIR: AT3G21430.3 DNA binding protein; Swiss-Prot: sp|Q6A332|ALY3_ARATH Protein ALWAYS EARLY 3; TrEMBL-Plants: tr|A0A0B2P6S5|A0A0B2P6S5_GLYSO Protein ALWAYS EARLY 3; Found in the gene: LotjaGi4g1v0344700
Domains
18
LotjaGi4g1v0344700.2
– Always EARLY-like protein; TAIR: AT3G21430.3 DNA binding protein; Swiss-Prot: sp|Q6A332|ALY3_ARATH Protein ALWAYS EARLY 3; TrEMBL-Plants: tr|A0A0B2P6S5|A0A0B2P6S5_GLYSO Protein ALWAYS EARLY 3; Found in the gene: LotjaGi4g1v0344700
Domains
18
LotjaGi4g1v0344700.3
– Always EARLY-like protein; TAIR: AT3G21430.3 DNA binding protein; Swiss-Prot: sp|Q6A332|ALY3_ARATH Protein ALWAYS EARLY 3; TrEMBL-Plants: tr|A0A0B2P6S5|A0A0B2P6S5_GLYSO Protein ALWAYS EARLY 3; Found in the gene: LotjaGi4g1v0344700
Domains
18
LotjaGi5g1v0221200.1
– Always EARLY-like protein; TAIR: AT3G21430.3 DNA binding protein; Swiss-Prot: sp|Q6A332|ALY3_ARATH Protein ALWAYS EARLY 3; TrEMBL-Plants: tr|A0A0B2Q7U7|A0A0B2Q7U7_GLYSO Protein ALWAYS EARLY 3; Found in the gene: LotjaGi5g1v0221200
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 7.14