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IPR010678

Source: InterPro

Description

IPR010678 is a U3 small nucleolar RNA-associated protein 25.

<p>This family represents U3 small nucleolar RNA-associated protein 25 (UTP25), a DEAD-box RNA helicase-like protein component of the ribosomal small subunit processome for the biogenesis of ribosomes, which functions in pre-ribosomal RNA (pre-rRNA) processing. U3 small nucleolar RNA-associated protein 25 homologue (also known as Digestive organ expansion factor (DEF)) from animals is essential for embryonic development in part through the regulation of p53 pathway and controls the expansion growth of digestive organs and liver [[cite:PUB00097919], [cite:PUB00097921], [cite:PUB00097922]]. It is though to be also involved in the sympathetic neuronal development. UTP25 mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 [[cite:PUB00097921], [cite:PUB00097922]].</p> <p>Protein NUCLEOLAR FACTOR 1 from Arabidopsis thaliana (Nof1) is also included in this group. This protein is involved in the control of rRNA expression, embryo development and female gametogenesis [[cite:PUB00100328]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005634
Cellular component Nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj6g3v1357560.1
– PREDICTED: U3 small nucleolar RNA-associated protein 25-like isoform X1 [Cicer arietinum] gi|502095509|ref|XP_004490471.1|
Domains
6
LotjaGi6g1v0239900.1
– U3 small nucleolar RNA-associated protein 25; TAIR: AT1G17690.1 U3 small nucleolar RNA-associated protein; Swiss-Prot: sp|B6JX19|UTP25_SCHJY U3 small nucleolar RNA-associated protein 25; TrEMBL-Plants: tr|A0A151T5S0|A0A151T5S0_CAJCA Digestive organ expansion factor isogeny; Found in the gene: LotjaGi6g1v0239900
Domains
4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00