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IPR010971 is a Ubiquinone biosynthesis hydroxylase UbiH/COQ6.
<p>This entry represents a family of FAD-dependent hydroxylases (monooxygenases), which are all believed to act in the aerobic ubiquinone biosynthesis pathway [[cite:PUB00013848]]. In Escherichia coli, three enzyme activities have been described: UbiI, UbiH and UbiF [[cite:PUB00068672]]. UbiH and UbiF are similar to one another and form the basis of this subfamily. UbiI (also known as visC) [[cite:PUB00068672]] is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (also known as visB) [[cite:PUB00013761]]. Several other species appear to have three homologues in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, [[cite:PUB00013831]]) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Ubiquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. | ||
| Molecular function | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ubiquinone biosynthesis monooxygenase COQ6-like isoform X1 [Cicer arietinum] gi|502103130|ref|XP_004492209.1| | 20 | ||
| – | PREDICTED: ubiquinone biosynthesis monooxygenase COQ6-like isoform X1 [Cicer arietinum] gi|502103130|ref|XP_004492209.1| | 19 | ||
| – | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TAIR: AT3G24200.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|Q6DF46|COQ6_XENTR Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TrEMBL-Plants: tr|V7B491|V7B491_PHAVU Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; Found in the gene: LotjaGi1g1v0594000 | 19 | ||
| – | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TAIR: AT3G24200.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|Q6DF46|COQ6_XENTR Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TrEMBL-Plants: tr|V7B491|V7B491_PHAVU Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; Found in the gene: LotjaGi5g1v0104700 | 18 | ||
| – | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TAIR: AT3G24200.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|Q6DF46|COQ6_XENTR Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TrEMBL-Plants: tr|A0A0B2PND5|A0A0B2PND5_GLYSO Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; Found in the gene: LotjaGi5g1v0104700 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01988 | TIGRFAM | 1 | 20.00 |