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IPR018168 is a Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site.
<p>This entry represents FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway [[cite:PUB00013848]]. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions [[cite:PUB00013779]]. In Escherichia coli, three enzyme activities have been described: UbiB (which acts first at position 6, see [interpro:IPR010232]), UbiH (which acts at position 4, [[cite:PUB00013809]]) and UbiF (which acts at position 5, [[cite:PUB00013834]]). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB) [[cite:PUB00013761]]. Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, [[cite:PUB00013831]]) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF.</p> <p>This entry represents the conserved site of the ubiquinone biosynthesis hydroxylase enzyme.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ubiquinone biosynthesis monooxygenase COQ6-like isoform X1 [Cicer arietinum] gi|502103130|ref|XP_004492209.1| | 20 | ||
| – | PREDICTED: ubiquinone biosynthesis monooxygenase COQ6-like isoform X1 [Cicer arietinum] gi|502103130|ref|XP_004492209.1| | 19 | ||
| – | Ubiquinone biosynthesis monooxygenase COQ6 [Medicago truncatula] gi|357450967|ref|XP_003595760.1| | 10 | ||
| – | 10 | |||
| – | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TAIR: AT3G24200.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|Q6DF46|COQ6_XENTR Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TrEMBL-Plants: tr|V7B491|V7B491_PHAVU Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; Found in the gene: LotjaGi1g1v0594000 | 19 | ||
| – | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TAIR: AT3G24200.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|Q9Y2Z9|COQ6_HUMAN Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TrEMBL-Plants: tr|A0A0L9U4M4|A0A0L9U4M4_PHAAN Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; Found in the gene: LotjaGi1g1v0594000 | 10 | ||
| – | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TAIR: AT3G24200.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|Q6DF46|COQ6_XENTR Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TrEMBL-Plants: tr|V7B491|V7B491_PHAVU Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; Found in the gene: LotjaGi5g1v0104700 | 18 | ||
| – | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TAIR: AT3G24200.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|Q6DF46|COQ6_XENTR Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; TrEMBL-Plants: tr|A0A0B2PND5|A0A0B2PND5_GLYSO Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; Found in the gene: LotjaGi5g1v0104700 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01988 | TIGRFAM | 1 | 12.50 |