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IPR011494 is a Protein HIRA-like, C-terminal.
<p>This entry represents a domain found at the C-terminal end of the HIRA proteins, which mediates homooligomerization [[cite:PUB00103806]].</p> <p>The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin, including Hir1/2 from yeast and the orthologue from human, HIRA (also known as TUP1-like enhancer of split protein 1). These proteins contain a WD40 repeat ([interpro:IPR001680]) at the N-terminal a central B domain and a C domain at the C-terminal [[cite:PUB00103806], [cite:PUB00043990]].</p> <p>HIRA/Hir1/2 cooperate with ASF1A to promote replication-independent chromatin assembly. It is also required for the periodic repression of histone gene transcription during the cell cycle and for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit [[cite:PUB00103532], [cite:PUB00077872], [cite:PUB00103531]]. Human HIRA is associated with the the DiGeorge syndrome, a developmental disorder [[cite:PUB00019699]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein HIRA-like [Glycine max] gi|356543582|ref|XP_003540239.1| | 6 | ||
| – | WD-repeat protein, putative; TAIR: AT3G44530.2 histone chaperone HIRA-like protein; Swiss-Prot: sp|Q9LXN4|HIRA_ARATH Protein HIRA; TrEMBL-Plants: tr|K7LVP9|K7LVP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0175400 | 19 | ||
| – | WD-repeat protein, putative; TAIR: AT3G44530.2 histone chaperone HIRA-like protein; Swiss-Prot: sp|Q9LXN4|HIRA_ARATH Protein HIRA; TrEMBL-Plants: tr|K7LVP9|K7LVP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0175400 | 19 | ||
| – | Protein HIRA; TAIR: AT3G44530.3 histone chaperone HIRA-like protein; Swiss-Prot: sp|Q9LXN4|HIRA_ARATH Protein HIRA; TrEMBL-Plants: tr|K7LVP9|K7LVP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0175400 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |