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IPR012004

Source: InterPro

Description

IPR012004 is a Pyrophosphate-dependent phosphofructokinase TP0108-type.

<p>Phosphofructokinase (PFK) catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate, which then enters the Embden-Meyerhof pathway. PFK is a key regulatory enzyme in glycolysis [[cite:PUB00013528]].</p> <p>This family consists of a group of plant and bacterial pyrophosphate-dependent phosphofructokinases related to TP0108 from Treponema [[cite:PUB00014446]]. The bacterial versions are non-allosteric dimers, while the plant versions are allosteric heterotetramers [[cite:PUB00014390]]. They belong to the PFK domain superfamily of proteins, which also includes prokaryotic ([interpro:IPR012003]) and eukaryotic ATP-dependent PFKs ([interpro:IPR009161]). The membership of this group largely resembles group B1 PFKs [[cite:PUB00014634]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003872
Molecular function 6-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0006096
Biological process Glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
Subterm of

Associated Lotus transcripts 17

Transcript Name Description Predicted domains Domain count
Lj0g3v0258989.1
– 6-phosphofructokinase [Medicago truncatula] gi|357517251|ref|XP_003628914.1|
Domains
10
Lj1g3v2095500.1
– PREDICTED: 6-phosphofructokinase 3-like [Glycine max] gi|356515641|ref|XP_003526507.1|
Domains
12
Lj2g3v1453880.1
– PREDICTED: 6-phosphofructokinase 5, chloroplastic-like [Cicer arietinum] gi|502092757|ref|XP_004489766.1|
Domains
10
Lj3g3v0290220.2
– PREDICTED: 6-phosphofructokinase 3-like [Glycine max] gi|356550484|ref|XP_003543617.1|
Domains
11
Lj4g3v0095120.1
– PREDICTED: 6-phosphofructokinase 2-like [Cicer arietinum] gi|502126527|ref|XP_004499341.1|
Domains
11
LotjaGi1g1v0409800.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT4G26270.1 phosphofructokinase 3; Swiss-Prot: sp|Q94AA4|PFKA3_ARATH ATP-dependent 6-phosphofructokinase 3; TrEMBL-Plants: tr|A0A151TST4|A0A151TST4_CAJCA ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi1g1v0409800
Domains
14
LotjaGi2g1v0227800.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT4G26270.1 phosphofructokinase 3; Swiss-Prot: sp|Q94AA4|PFKA3_ARATH ATP-dependent 6-phosphofructokinase 3; TrEMBL-Plants: tr|V7C472|V7C472_PHAVU ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi2g1v0227800
Domains
13
LotjaGi2g1v0227800.2
– ATP-dependent 6-phosphofructokinase; TAIR: AT4G26270.1 phosphofructokinase 3; Swiss-Prot: sp|Q94AA4|PFKA3_ARATH ATP-dependent 6-phosphofructokinase 3; TrEMBL-Plants: tr|V7C472|V7C472_PHAVU ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi2g1v0227800
Domains
13
LotjaGi2g1v0227800.3
– ATP-dependent 6-phosphofructokinase; TAIR: AT4G26270.1 phosphofructokinase 3; Swiss-Prot: sp|Q94AA4|PFKA3_ARATH ATP-dependent 6-phosphofructokinase 3; TrEMBL-Plants: tr|V7C472|V7C472_PHAVU ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi2g1v0227800
Domains
12
LotjaGi2g1v0326200.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT2G22480.1 phosphofructokinase 5; Swiss-Prot: sp|Q8VYN6|PFKA5_ARATH ATP-dependent 6-phosphofructokinase 5, chloroplastic; TrEMBL-Plants: tr|I1J525|I1J525_SOYBN ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi2g1v0326200
Domains
12
LotjaGi2g1v0326200.2
– ATP-dependent 6-phosphofructokinase; TAIR: AT2G22480.1 phosphofructokinase 5; Swiss-Prot: sp|Q8VYN6|PFKA5_ARATH ATP-dependent 6-phosphofructokinase 5, chloroplastic; TrEMBL-Plants: tr|I1J525|I1J525_SOYBN ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi2g1v0326200
Domains
12
LotjaGi3g1v0022100.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT4G26270.1 phosphofructokinase 3; Swiss-Prot: sp|Q94AA4|PFKA3_ARATH ATP-dependent 6-phosphofructokinase 3; TrEMBL-Plants: tr|I1M5F6|I1M5F6_SOYBN ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi3g1v0022100
Domains
12
LotjaGi3g1v0022100.2
– ATP-dependent 6-phosphofructokinase; TAIR: AT4G26270.1 phosphofructokinase 3; Swiss-Prot: sp|Q94AA4|PFKA3_ARATH ATP-dependent 6-phosphofructokinase 3; TrEMBL-Plants: tr|I1MCW0|I1MCW0_SOYBN ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi3g1v0022100
Domains
13
LotjaGi4g1v0004400.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT5G47810.1 phosphofructokinase 2; Swiss-Prot: sp|Q9FIK0|PFKA2_ARATH ATP-dependent 6-phosphofructokinase 2; TrEMBL-Plants: tr|V7CAY4|V7CAY4_PHAVU ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi4g1v0004400
Domains
12
LotjaGi4g1v0160800.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT2G22480.1 phosphofructokinase 5; Swiss-Prot: sp|Q8VYN6|PFKA5_ARATH ATP-dependent 6-phosphofructokinase 5, chloroplastic; TrEMBL-Plants: tr|G7LJ94|G7LJ94_MEDTR ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi4g1v0160800
Domains
11
LotjaGi4g1v0443300.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT4G26270.1 phosphofructokinase 3; Swiss-Prot: sp|Q94AA4|PFKA3_ARATH ATP-dependent 6-phosphofructokinase 3; TrEMBL-Plants: tr|G7L7C4|G7L7C4_MEDTR ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi4g1v0443300
Domains
13
LotjaGi5g1v0257100.1
– ATP-dependent 6-phosphofructokinase; TAIR: AT5G61580.1 phosphofructokinase 4; Swiss-Prot: sp|Q9FKG3|PFKA4_ARATH ATP-dependent 6-phosphofructokinase 4, chloroplastic; TrEMBL-Plants: tr|I1LCJ1|I1LCJ1_SOYBN ATP-dependent 6-phosphofructokinase; Found in the gene: LotjaGi5g1v0257100
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53784 SUPERFAMILY 1 5.88