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IPR012135

Source: InterPro

Description

IPR012135 is a Dihydroorotate dehydrogenase, class 1/ 2.

<p>Dihydroorotate dehydrogenase (DHOD), also known as dihydroorotate oxidase, catalyses the fourth step in de novo pyrimidine biosynthesis, the stereospecific oxidation of (S)-dihydroorotate to orotate, which is the only redox reaction in this pathway. DHODs can be divided into two mains classes: class 1 cytosolic enzymes found primarily in Gram-positive bacteria, and class 2 membrane-associated enzymes found primarily in eukaryotic mitochondria and Gram-negative bacteria [[cite:PUB00033267]].</p> <p>The class 1 DHODs can be further divided into subclasses 1A and 1B, which differ in their structural organisation and use of electron acceptors. The 1A enzyme is a homodimer of two PyrD subunits where each subunit forms a TIM barrel fold with a bound FMN cofactor located near the top of the barrel [[cite:PUB00005052]]. Fumarate is the natural electron acceptor for this enzyme. The 1B enzyme, in contrast is a heterotetramer composed of a central, FMN-containing, PyrD homodimer resembling the 1A homodimer, and two additional PyrK subunits which contain FAD and a 2Fe-2S cluster [[cite:PUB00024613]]. These additional groups allow the enzyme to use NAD(+) as its natural electron acceptor.</p> <p>The class 2 membrane-associated enzymes are monomers which have the FMN-containing TIM barrel domain found in the class 1 PyrD subunit, and an additional N-terminal α helical domain [[cite:PUB00024104], [cite:PUB00033268]]. These enzymes use respiratory quinones as the physiological electron acceptor.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004152
Molecular function Dihydroorotate dehydrogenase activity Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
Subterm of
GO:0006222
Biological process UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj2g3v0658080.2
– Dihydropyrimidine dehydrogenase [Medicago truncatula] gi|357499179|ref|XP_003619878.1|
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF51395 SUPERFAMILY 1 100.00