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IPR005720 is a Dihydroorotate dehydrogenase, catalytic.
<p>This entry represents a domain found in dihydroorotate and dihydropyrimidine dehydrogenases. Dihydroorotate dehydrogenases included in this entry catalyse the conversion of dihydroorotate to orotate using quinone, fumarate and NAD+ as electron acceptor [[cite:PUB00056837]]. Dihydropyrimidine dehydrogenases catalyse the conversion of 5,6-dihydrouracil to uracil and are involved in pyrimidine base degradation [[cite:PUB00153011]].</p> <p>Dihydroorotate dehydrogenase ([ec:1.3.98.1]) (DHOdehase) catalyses the fourth step in the <i>de novo</i> biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein. In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene URA1, subfamily 2), it is a cytosolic protein while in other eukaryotes it is found in the mitochondria [[cite:PUB00004801]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Molecular function | Oxidoreductase activity, acting on the CH-CH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial-like [Glycine max] gi|356536427|ref|XP_003536739.1| | 17 | ||
| – | PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial-like [Glycine max] gi|356536427|ref|XP_003536739.1| | 19 | ||
| – | PREDICTED: NAD-dependent dihydropyrimidine dehydrogenase subunit PreA-like [Glycine max] gi|356520655|ref|XP_003528976.1| | 9 | ||
| – | Dihydropyrimidine dehydrogenase [Medicago truncatula] gi|357499179|ref|XP_003619878.1| | 9 | ||
| – | Dihydroorotate dehydrogenase (Quinone); TAIR: AT3G17810.1 pyrimidine 1; Swiss-Prot: sp|Q9LVI9|DPYD_ARATH Dihydropyrimidine dehydrogenase (NADP(+)), chloroplastic; TrEMBL-Plants: tr|I1KJ84|I1KJ84_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0192600 | 9 | ||
| – | Dihydroorotate dehydrogenase (Quinone); TAIR: AT5G23300.1 pyrimidine d; Swiss-Prot: sp|P32746|PYRD_ARATH Dihydroorotate dehydrogenase (quinone), mitochondrial; TrEMBL-Plants: tr|I1LF90|I1LF90_SOYBN Dihydroorotate dehydrogenase (quinone), mitochondrial; Found in the gene: LotjaGi5g1v0353100 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |