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IPR012429

Description

IPR012429 is a Heparan-alpha-glucosaminide N-acetyltransferase, catalytic domain.

<p>Heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the transmembrane acetylation of heparan sulfate in lysosomes required for its further catabolism. Mutations of the HGSNAT gene cause the neurodegenerative disease mucopolysaccharidosis IIIC (MPS IIIC) [[cite:PUB00090705]].</p> <p>This entry represents the catalytic domain of HGSNAT which contains the conserved histidine in the active site (His269), thought to hold the acetyl group during the transfer across the membrane and required for its enzymatic activity [[cite:PUB00090705]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase-like isoform X2 [Cicer arietinum] gi|502090117|ref|XP_004489126.1| 9
PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase-like [Glycine max] gi|356516509|ref|XP_003526936.1| 8
PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase-like [Glycine max] gi|356503734|ref|XP_003520659.1| 9
Heparan-alpha-glucosaminide N-acetyltransferase; TAIR: AT5G47900.1 heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624); Swiss-Prot: sp|Q3UDW8|HGNAT_MOUSE Heparan-alpha-glucosaminide N-acetyltransferase; TrEMBL-Plants: tr|I3SPG2|I3SPG2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0552000 9
Aquaporin; TAIR: AT4G35100.1 plasma membrane intrinsic protein 3; Swiss-Prot: sp|P93004|PIP27_ARATH Aquaporin PIP2-7; TrEMBL-Plants: tr|I6XCT2|I6XCT2_LINUS Putative aquaporin PIP2-8; Found in the gene: LotjaGi1g1v0558200 18
Heparan-alpha-glucosaminide N-acetyltransferase; TAIR: AT5G47900.1 heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624); Swiss-Prot: sp|Q3UDW8|HGNAT_MOUSE Heparan-alpha-glucosaminide N-acetyltransferase; TrEMBL-Plants: tr|I1K6Y3|I1K6Y3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0558200 8
Heparan-alpha-glucosaminide N-acetyltransferase; TAIR: AT5G27730.1 heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624); Swiss-Prot: sp|Q3UDW8|HGNAT_MOUSE Heparan-alpha-glucosaminide N-acetyltransferase; TrEMBL-Plants: tr|A0A0R0KSG2|A0A0R0KSG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0686700 9
Heparan-alpha-glucosaminide N-acetyltransferase; TAIR: AT5G27730.1 heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624); Swiss-Prot: sp|Q3UDW8|HGNAT_MOUSE Heparan-alpha-glucosaminide N-acetyltransferase; TrEMBL-Plants: tr|A0A0R0KSG2|A0A0R0KSG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0686700 9
Heparan-alpha-glucosaminide N-acetyltransferase; TAIR: AT5G27730.3 heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624); Swiss-Prot: sp|Q3UDW8|HGNAT_MOUSE Heparan-alpha-glucosaminide N-acetyltransferase; TrEMBL-Plants: tr|A0A0R0KSG2|A0A0R0KSG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0686700 8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 11.11