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IPR012748 is a Rieske-like [2Fe-2S] domain, NirD-type.
<p>In Proteobacteria and Actinobacteria the main nitrite reductase activity is contributed by the NADH-dependent nitrite reductase, which detoxifies the nitrite formed as the product of nitrate reduction. The NADH-nitrite reductase operon consists of 4 genes: nirB, nirD, nirC and cysG. The enzyme is formed by the two subunits nirB and nirD. NirC is a nitrite transporter and cysG is required for the synthesis of sirohaem, a cofactor of the nirB subunit [[cite:PUB00043673], [cite:PUB00043674]]. NirD displays some sequence similarities with the 2Fe-2S Rieske domain (see [prositedoc:PDOC00177]), but it does not contain the essential residues for the coordination of the iron sulphur [[cite:PUB00080966], [cite:PUB00043837]].</p> <p>The entry includes the NirD subunit. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while fungal proteins have a C-terminal Rieske domain in addition to several other domains. The fungal NirD is involved in nutrient acquisition, functioning at the soil/fungus interface to control nutrient exchange between the fungus and the host plant [[cite:PUB00080961], [cite:PUB00014871]]. The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The Rieske [2Fe-2S] cluster is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs [[cite:PUB00043836]]. In this family, only a few members contain these residues. Other members may have lost the ability to bind the Rieske [2Fe-2S] cluster.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nitrite reductase [NAD(P)H] activity | Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Os11g0242400 [Oryza sativa Japonica Group] gi|115484891|ref|NP_001067589.1| | 9 | ||
| – | Photosystem II 22 kDa protein; TAIR: AT1G71500.1 Rieske (2Fe-2S) domain-containing protein; Swiss-Prot: sp|P51355|YCF17_PORPU Uncharacterized protein ycf17; TrEMBL-Plants: tr|A0A151SCU8|A0A151SCU8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0444900 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03467 | CDD | 1 | 50.00 |