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IPR012890 is a Intron Large complex component GCFC2-like.
<p>This entry includes GCFC2 and PAXBP1 from humans, and ILP1 from Arabidopsis thaliana. GCFC2 is involved in pre-mRNA splicing through regulating spliceosome C complex formation [[cite:PUB00088153]]. ILP1 and its orthologue in mouse have been shown to be repressors of cyclin genes. In Arabidopsis, all members of the CYCLINA2 family are repressed, and in mouse cyclin A2. The CYCLINA2 cyclins control endoreduplication, in which DNA is replicated but the cell cyle continues without cell division leading to polyploidy. ILP1 therefore regulates endoreduplication through control of CYCA2 expression in Arabidopsis [[cite:PUB00082606]]. ILP1 has been shown to be required for efficient splicing [[cite:PUB00088155]].</p> <p>It's worth noting that GCFC2 was originally thought to be a DNA-binding transcriptional repressor. However, later work showed that the original sequence was a chimera and that the DNA-binding activity was derived from the incorrect N-terminal sequence [[cite:PUB00095627]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: GC-rich sequence DNA-binding factor 1-like [Glycine max] gi|356577171|ref|XP_003556701.1| | 9 | ||
| – | GC-rich sequence DNA-binding factor 1; TAIR: AT5G08550.1 GC-rich sequence DNA-binding factor-like protein; Swiss-Prot: sp|Q9FNN3|ILP1_ARATH Transcriptional repressor ILP1; TrEMBL-Plants: tr|A0A151T9J7|A0A151T9J7_CAJCA GC-rich sequence DNA-binding factor isogeny; Found in the gene: LotjaGi3g1v0022300 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |