Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR012901 is a Carnosine N-methyltransferase.
<p>This family includes Carnosine N-methyltransferase ([ec:2.1.1.22]), conserved from yeast to human, that catalyses the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. It also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His) [[cite:PUB00098813], [cite:PUB00098814], [cite:PUB00098815]].</p> <p>Carnosine N-methyltransferase unmet from Drosophila melanogaster, acts as a sensor to signal methionine availability to the mTORC1 signaling pathway [[cite:PUB00158949]]. It associates with the GATOR2 complex in the absence of methionine to inhibit mTORC1 signalling, but dissociates in the presence of the methionine derivative S-adenosyl-L-methionine; S-adenosyl-L-homocysteine binding does not induce dissociation [[cite:PUB00158949]]. It is required for mTORC1 pathway response to methionine starvation [[cite:PUB00158949]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: UPF0586 protein C9orf41 homolog [Cicer arietinum] gi|502134316|ref|XP_004502075.1| | 9 | ||
| – | PREDICTED: UPF0586 protein C9orf41 homolog [Glycine max] gi|356551269|ref|XP_003543999.1| | 8 | ||
| – | S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; TAIR: AT2G32170.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q80UY1|CARME_MOUSE Carnosine N-methyltransferase; TrEMBL-Plants: tr|I1LXK8|I1LXK8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0035200 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |