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IPR013644 is a 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal.
<p>This domain is found to the C terminus of [interpro:IPR013512] domains in bacterial and plant 1-deoxy-D-xylulose 5-phosphate reductoisomerases. This domain has been related to the dimer formation, for providing residues necessary for active site metal binding, and for positioning the substrate [[cite:PUB00099841]].</p> <p>1-deoxy-D-xylulose 5-phosphate reductoisomerase synthesises 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate in a single step by intramolecular rearrangement and reduction and is responsible for terpenoid biosynthesis in some organisms [[cite:PUB00020977], [cite:PUB00099840]]. In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective.</p> <p>The structure of this enzyme has been solved, showing the protein forms a dimeric assembly and contains a metal ion in the active site [[cite:PUB00099841]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic-like [Cicer arietinum] gi|502155936|ref|XP_004510245.1| | 11 | ||
| – | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic-like [Glycine max] gi|358248074|ref|NP_001240062.1| | 19 | ||
| – | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; TAIR: AT5G62790.1 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Swiss-Prot: sp|Q8W250|DXR_ORYSJ 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic; TrEMBL-Plants: tr|I3SQW6|I3SQW6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0087700 | 20 | ||
| – | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; TAIR: AT5G62790.1 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Swiss-Prot: sp|Q8W250|DXR_ORYSJ 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic; TrEMBL-Plants: tr|A0A151S841|A0A151S841_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0234600 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00243 | TIGRFAM | 1 | 25.00 |