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IPR013751 is a Beta-ketoacyl-[acyl-carrier-protein] synthase III, N-terminal.
<p>Fatty acid synthesis (FAS) is a vital aspect of cellular physiology which can occur by two distinct pathways. The FAS I pathway, which generally only produces palmitate, is found in eukaryotes and is performed either by a single polypeptide which contains all the reaction centres needed to form a fatty acid, or by two polypeptides which interact to form a multifunctional complex. The FAS II pathway, which is capable of producing many different fatty acids, is found in mitochondria, bacteria, plants and parasites, and is performed by many distinct proteins, each of which catalyses a single step within the pathway. The large diversity of products generated by this pathway is possible because the acyl carrier protein (ACP) intermediates are diffusible entities that can be diverted into other biosynthetic pathways [[cite:PUB00033355]].</p> <p>3-Oxoacyl-[acyl carrier protein (ACP)] synthase III catalyses the first condensation step within the FAS II pathway, using acetyl-CoA as the primer and malonyl-ACP as the acceptor, as shown below.</p> <p><reaction>Acyl-[ACP] + malonyl-[ACP] = 3-oxoacyl-[ACP] + CO(2) + [ACP]</reaction></p> <p>The oxoacyl-ACP formed by this reaction subsequently enters the elongation cycle, where the acyl chain is progressively lengthened by the combined activities of several enzymes.</p> <p>The enzymes studied so far are homodimers, where each monomer consists of two domains (N-terminal and C-terminal) which are similar in structure, but not in sequence [[cite:PUB00025721], [cite:PUB00033354]].</p> <p>This entry represents a conserved region within the N-terminal domain.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. | ||
| Biological process | Fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 3-oxoacyl-[acyl]-carrier-protein] gi|356532179|ref|XP_003534651.1| | 10 | ||
| – | 3-oxoacyl-[acyl]-carrier-protein] synthase 3; TAIR: AT1G62640.1 3-ketoacyl-acyl carrier protein synthase III; Swiss-Prot: sp|P49244|FABH1_CUPWR 3-oxoacyl-[acyl]-carrier-protein] synthase 3 A, chloroplastic; TrEMBL-Plants: tr|A0A151RJB7|A0A151RJB7_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0004000 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00830 | CDD | 1 | 50.00 |