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IPR013970 is a Replication factor A protein 3.
<p>Rfa3 (also known as RPA14) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [[cite:PUB00070983]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Biological process | DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Similar to signal recognition particle 54 kDa protein [Lupinus angustifolius] gi|440583671|emb|CCH47177.1| | 8 | ||
| – | Nucleic acid-binding, OB-fold-like protein [Theobroma cacao] gi|508716376|gb|EOY08273.1| | 8 | ||
| – | Replication protein A 14 kDa subunit B; TAIR: AT4G18590.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q6NLG7|RFA3B_ARATH Replication protein A 14 kDa subunit B; TrEMBL-Plants: tr|I3SDU0|I3SDU0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0675300 | 8 | ||
| – | Replication protein A 14 kDa subunit B; TAIR: AT3G52630.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q9LXK1|RFA3A_ARATH Replication protein A 14 kDa subunit A; TrEMBL-Plants: tr|I3SI76|I3SI76_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0344400 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04479 | CDD | 1 | 25.00 |