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IPR014445 is a Glutamine-dependent NAD(+) synthetase.
<p>This group represents the glutamine-dependent NAD(+) synthetases with the GAT domain from archaea, bacteria to humans.</p> <p>NAD+ is involved electron transport and redox reactions and in DNA ligation and protein ADP-ribosylation. In yeast and most other organisms, NAD is generated through the de novo pathway and the salvage pathway. In the de novo pathway, quinolinic acid is converted to nicotinic acid mononucleotide (NaMN). In the salvage pathway, NaMN is generated by recycling of nicotinamide. Both pathways converge on NaMN, which is then converted into deamido-NAD+. Subsequently, deamido-NAD+ is converted to NAD+ by NAD+ synthetase [[cite:PUB00070122]].</p> <p>NAD+ synthetase has been extensively studied in bacteria. It is encoded by nadE gene in E. coli and by outB gene in B. subtilis [[cite:PUB00070123]]. However, these enzymes are ammonia-dependent (containing an ammonia-utilising domain) and are not included in this entry [[cite:PUB00070124]]. The pokaryotic proteins in this family, such as that from Mycobacterium tuberculosis, contain a nitrilase-related domain, are glutamine-dependent and are included in this entry [[cite:PUB00070124]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | NAD+ synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glutamine-dependent NAD(+) synthetase-like [Glycine max] gi|356523661|ref|XP_003530455.1| | 16 | ||
| – | PREDICTED: glutamine-dependent NAD(+) synthetase-like [Glycine max] gi|356523661|ref|XP_003530455.1| | 17 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|I1KPN4|I1KPN4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438000 | 19 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|I1KPN4|I1KPN4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438000 | 19 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|A0A0R0K490|A0A0R0K490_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438000 | 17 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|I1KPN4|I1KPN4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438100 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07570 | CDD | 1 | 16.67 |