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IPR022310 is a NAD/GMP synthase.
<p>NAD+ synthase ([ec:6.3.5.1]) catalyzes the last step in the biosynthesis of nicotinamide adenine dinucleotide and is induced by stress factors such as heat shock and glucose limitation. The three-dimensional structure of NH3-dependent NAD+ synthetase from Bacillus subtilis, in its free form and in complex with ATP shows that the enzyme consists of a tight homodimer with alpha/beta subunit topology [[cite:PUB00008175]].</p> <p>This domain is also found in guanosine 5'-monophosphate (GMP) synthetase. GMP synthase catalyses the synthesis of GMP from XMP. The protein is a homodimer, but in some archaea it is a heterodimer composed of a glutamine amidotransferase subunit and a ATP pyrophosphatase subunit. In eucaryotes, bacteria, and some archaea the two catalytic units are encoded by a single gene, producing a two-domain-type GMP, with a GATase domain in the N-terminal half and a ATP-PPase domain in the C-terminal half. This entry represents the ATP pyrophosphatase domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glutamine-dependent NAD(+) synthetase-like [Glycine max] gi|356523661|ref|XP_003530455.1| | 16 | ||
| – | PREDICTED: glutamine-dependent NAD(+) synthetase-like [Glycine max] gi|356523661|ref|XP_003530455.1| | 17 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|I1KPN4|I1KPN4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438000 | 19 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|I1KPN4|I1KPN4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438000 | 19 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|A0A0R0K490|A0A0R0K490_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438000 | 17 | ||
| – | NH(3)-dependent NAD(+) synthetase; TAIR: AT1G55090.1 carbon-nitrogen hydrolase family protein; Swiss-Prot: sp|Q9C723|NADE_ARATH Glutamine-dependent NAD(+) synthetase; TrEMBL-Plants: tr|I1KPN4|I1KPN4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0438100 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07570 | CDD | 1 | 16.67 |