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IPR014752 is a Arrestin-like, C-terminal.
<p>Arrestins comprise a family of closely-related proteins. In addition to the inactivation of G protein-coupled receptors, arrestins have been implicated in the endocytosis of receptors and cross talk with other signalling pathways. S-Arrestin (retinal S-antigen) is a major protein of the retinal rod outer segments. It interacts with photo-activated phosphorylated rhodopsin, inhibiting or 'arresting' its ability to interact with transducin [[cite:PUB00001029]]. Beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X) [[cite:PUB00001684]], which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction [[cite:PUB00000986], [cite:PUB00002739], [cite:PUB00005126]]. The crystal structure of bovine retinal arrestin comprises two domains of antiparallel β-sheets connected through a hinge region and one short α-helix on the back of the amino-terminal fold [[cite:PUB00004275]].</p> <p>This superfamily represents the C-terminal domain of arrestin, and Vacuolar protein sorting protein 26 (VPS26), consisting of an immunoglobulin-like β-sandwich structure.</p> <p>VPS26 assembles into a multimeric complex with other vacuolar protein sorting proteins (VPSs) and plays a role in vesicular protein sorting [[cite:PUB00007754]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Down syndrome critical region protein 3 like; TAIR: AT1G48550.1 Vacuolar protein sorting-associated protein 26; Swiss-Prot: sp|O14972|DSCR3_HUMAN Down syndrome critical region protein 3; TrEMBL-Plants: tr|A0A151TEM0|A0A151TEM0_CAJCA Down syndrome critical region protein 3 isogeny; Found in the gene: LotjaGi2g1v0196200 | 8 | ||
| – | Down syndrome critical region protein 3 like; TAIR: AT1G48550.1 Vacuolar protein sorting-associated protein 26; Swiss-Prot: sp|O35075|DSCR3_MOUSE Down syndrome critical region protein 3 homolog; TrEMBL-Plants: tr|A0A151TEM0|A0A151TEM0_CAJCA Down syndrome critical region protein 3 isogeny; Found in the gene: LotjaGi2g1v0196200 | 8 | ||
| – | Vacuolar protein sorting-associated; TAIR: AT5G53530.1 vacuolar protein sorting 26A; Swiss-Prot: sp|Q9FJD0|VP26A_ARATH Vacuolar protein sorting-associated protein 26A; TrEMBL-Plants: tr|A0A072TM21|A0A072TM21_MEDTR Vacuolar protein sorting-associated protein 26A; Found in the gene: LotjaGi3g1v0373900 | 8 | ||
| – | Vacuolar protein sorting-associated; TAIR: AT5G53530.1 vacuolar protein sorting 26A; Swiss-Prot: sp|Q9FJD0|VP26A_ARATH Vacuolar protein sorting-associated protein 26A; TrEMBL-Plants: tr|A0A072TM21|A0A072TM21_MEDTR Vacuolar protein sorting-associated protein 26A; Found in the gene: LotjaGi3g1v0373900 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF81296 | SUPERFAMILY | 1 | 25.00 |