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IPR015252 is a Breast cancer type 2 susceptibility protein, helical domain.
<p>This entry represents a domain found in BRCA2 proteins. This domain adopts a helical structure, consisting of a four-helix cluster core (α1, α8, α9, α10) and two successive β-hairpins (β1 to β4). An approximately 50-amino acid segment that contains four short helices (α2 to α4), meanders around the surface of the core structure. In BRCA2, the α9 and α10 helices pack with BRCA-2_OB1 ([interpro:IPR015187]) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. This domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [[cite:PUB00021040]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein BRCA2-like B [Arabidopsis thaliana] gi|42567571|ref|NP_195783.3| | 9 | ||
| – | Protein BRCA2-like B [Arabidopsis thaliana] gi|42567571|ref|NP_195783.3| | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |