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IPR015865 is a Riboflavin kinase domain, bacterial/eukaryotic.
<p>Riboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin kinase ([ec:2.7.1.26]), which converts it into FMN, and FAD synthetase ([ec:2.7.7.2]), which adenylates FMN to FAD. Eukaryotes usually have two separate enzymes, while most prokaryotes have a single bifunctional protein that can carry out both catalyses, although exceptions occur in both cases. While eukaryotic monofunctional riboflavin kinase is orthologous to the bifunctional prokaryotic enzyme [[cite:PUB00030175]], the monofunctional FAD synthetase differs from its prokaryotic counterpart, and is instead related to the PAPS-reductase family [[cite:PUB00035657]]. The bacterial FAD synthetase that is part of the bifunctional enzyme has remote similarity to nucleotidyl transferases and, hence, it may be involved in the adenylylation reaction of FAD synthetases [[cite:PUB00010127]].</p> <p>This entry represents the riboflavin kinase domains from bacteria and eukaryotes.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Riboflavin kinase activity | Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). | ||
| Biological process | Riboflavin biosynthetic process | The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pseudouridine-5'-monophosphatase-like [Cicer arietinum] gi|502142477|ref|XP_004504977.1| | 17 | ||
| – | PREDICTED: pseudouridine-5'-monophosphatase-like [Glycine max] gi|356521303|ref|XP_003529296.1| | 9 | ||
| – | PREDICTED: riboflavin kinase-like [Glycine max] gi|356527927|ref|XP_003532557.1| | 9 | ||
| – | Riboflavin kinase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|A0A0S3QZS5|A0A0S3QZS5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0764100 | 21 | ||
| – | Riboflavin kinase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|A0A0S3QZS5|A0A0S3QZS5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0764100 | 21 | ||
| – | Riboflavin kinase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|A0A0S3QZS5|A0A0S3QZS5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0764100 | 8 | ||
| – | Riboflavin kinase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|A0A151S8Q7|A0A151S8Q7_CAJCA Riboflavin kinase; Found in the gene: LotjaGi4g1v0049600 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01509 | TIGRFAM | 1 | 14.29 |