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IPR006439

Description

IPR006439 is a HAD hydrolase, subfamily IA.

<p>The Haloacid Dehalogenase (HAD) superfamily is defined by the presence of three short catalytic motifs [[cite:PUB00003337]]. The subfamilies are defined [[cite:PUB00009589]] based on the location and the observed or predicted fold of a so-called capping domain [[cite:PUB00009540]], or the absence of such a domain. Subfamily I consists of sequences in which the capping domain is found in between the first and second catalytic motifs. Subfamily II consists of sequences in which the capping domain is found between the second and third motifs. Subfamily III sequences have no capping domain in either of these positions.</p> <p>The Subfamily IA and IB capping domains are predicted by PSI-PRED to consist of an α-helical bundle. Subfamily IA and IB are separated based on an apparent phylogenetic bifurcation. Of the three motifs defining the HAD superfamily, the third has three variant forms: (1) hhhhsDxxx(x)D, (2) hhhhssxxx(x)D and (3) hhhhDDxxx(x)s where _s_ refers to a small amino acid and _h_ to a hydrophobic one. All three of these variants are found in subfamily IA.</p> <p>NOTE: Three variant models were created by TIGRFAMs with some overlap among them to cover subfamily IA. This serves the purpose of eliminating the overlap with models of more distantly related HAD subfamilies caused by an overly broad single model.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

Associated Lotus transcripts 68

Transcript Name Description Predicted domains Domain count
Haloacid dehalogenase-like hydrolase superfamily protein [Theobroma cacao] gi|508703590|gb|EOX95486.1| 10
Haloacid dehalogenase-like hydrolase (HAD) superfamily protein [Theobroma cacao] gi|508715596|gb|EOY07493.1| 11
PREDICTED: pseudouridine-5'-monophosphatase-like [Cicer arietinum] gi|502150234|ref|XP_004507854.1| 9
PREDICTED: protein CbbY, chromosomal-like [Glycine max] gi|356525461|ref|XP_003531343.1| 9
PREDICTED: haloacid dehalogenase-like hydrolase domain-containing protein 3-like [Cicer arietinum] gi|502108258|ref|XP_004493428.1| 14
Phosphoglycolate phosphatase [Medicago truncatula] gi|357440899|ref|XP_003590727.1| 16
PREDICTED: probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1-like [Glycine max] gi|356544052|ref|XP_003540469.1| 11
PREDICTED: protein CbbY-like [Cicer arietinum] gi|502133626|ref|XP_004501834.1| 17
Phosphoglycolate phosphatase [Medicago truncatula] gi|357507679|ref|XP_003624128.1| 15
Phosphoglycolate phosphatase [Medicago truncatula] gi|357507679|ref|XP_003624128.1| 14
PREDICTED: NHL repeat-containing protein 2-like [Glycine max] gi|356571070|ref|XP_003553704.1| 10
PREDICTED: NHL repeat-containing protein 2-like [Glycine max] gi|356571070|ref|XP_003553704.1| 27
PREDICTED: pseudouridine-5'-monophosphatase-like [Cicer arietinum] gi|502142477|ref|XP_004504977.1| 11
PREDICTED: pseudouridine-5'-monophosphatase-like [Cicer arietinum] gi|502142477|ref|XP_004504977.1| 17
Haloacid dehalogenase-like hydrolase domain-containing protein [Medicago truncatula] gi|357486883|ref|XP_003613729.1| 9
Haloacid dehalogenase-like hydrolase domain-containing protein [Medicago truncatula] gi|357486883|ref|XP_003613729.1| 12
Pyrophosphatase ppaX [Medicago truncatula] gi|357482283|ref|XP_003611427.1| 9
PREDICTED: phosphatase YfbT-like [Glycine max] gi|356513397|ref|XP_003525400.1| 9
Ripening-related protein-like hydrolase-like protein [Medicago truncatula] gi|357472811|ref|XP_003606690.1| 10
Ripening-related protein-like hydrolase-like protein [Medicago truncatula] gi|357454203|ref|XP_003597382.1| 11
PREDICTED: pseudouridine-5'-monophosphatase-like [Glycine max] gi|356546960|ref|XP_003541887.1| 11
PREDICTED: pseudouridine-5'-monophosphatase-like [Glycine max] gi|356546960|ref|XP_003541887.1| 13
Ripening-related protein-like hydrolase-like protein [Medicago truncatula] gi|357472811|ref|XP_003606690.1| 11
Haloacid dehalogenase-like hydrolase (HAD) superfamily protein [Theobroma cacao] gi|508715596|gb|EOY07493.1| 11
Haloacid dehalogenase-like hydrolase superfamily protein [Theobroma cacao] gi|508703590|gb|EOX95486.1| 10
Haloacid dehalogenase-like hydrolase (HAD) superfamily protein [Theobroma cacao] gi|508715596|gb|EOY07493.1| 11
Haloacid dehalogenase-like hydrolase domain-containing protein [Medicago truncatula] gi|357449159|ref|XP_003594856.1| 12
Haloacid dehalogenase-like hydrolase domain-containing protein [Medicago truncatula] gi|357449159|ref|XP_003594856.1| 12
Haloacid dehalogenase-like hydrolase; TAIR: AT3G48420.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q94K71|GPPL2_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein At3g48420; TrEMBL-Plants: tr|I3SW77|I3SW77_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0231100 22
Haloacid dehalogenase-like hydrolase family protein; TAIR: AT1G79790.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9S586|GPH1_PSEAE Phosphoglycolate phosphatase 1; TrEMBL-Plants: tr|I3SMA5|I3SMA5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0483700 16
Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT2G41250.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q5M969|NANP_RAT N-acylneuraminate-9-phosphatase; TrEMBL-Plants: tr|I3T9E2|I3T9E2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0666900 19
NHL repeat-containing protein 2; TAIR: AT1G56500.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|A4IF69|NHLC2_BOVIN NHL repeat-containing protein 2; TrEMBL-Plants: tr|I1NBR0|I1NBR0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0748400 36
NHL repeat-containing protein 2; TAIR: AT1G56500.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|A4IF69|NHLC2_BOVIN NHL repeat-containing protein 2; TrEMBL-Plants: tr|I1NBR0|I1NBR0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0748400 36
NHL repeat-containing protein 2; TAIR: AT1G56500.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|A4IF69|NHLC2_BOVIN NHL repeat-containing protein 2; TrEMBL-Plants: tr|A0A072U549|A0A072U549_MEDTR Haloacid dehalogenase-like hydrolase family protein; Found in the gene: LotjaGi1g1v0748400 33
Riboflavin kinase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|A0A0S3QZS5|A0A0S3QZS5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0764100 21
Riboflavin kinase/fmn hydrolase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|I1KLD6|I1KLD6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0764100 16
Riboflavin kinase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|A0A0S3QZS5|A0A0S3QZS5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0764100 21
Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT1G14310.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9CYW4|HDHD3_MOUSE Haloacid dehalogenase-like hydrolase domain-containing protein 3; TrEMBL-Plants: tr|I1J5P8|I1J5P8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0304800 17
Haloacid dehalogenase-like hydrolase; TAIR: AT5G59480.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|P53078|SDT1_YEAST Suppressor of disruption of TFIIS; TrEMBL-Plants: tr|G7JUV7|G7JUV7_MEDTR Haloacid dehalogenase-like hydrolase; Found in the gene: LotjaGi2g1v0375700 10
Haloacid dehalogenase-like hydrolase; TAIR: AT2G38740.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9ZVJ5|SGGP_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp; TrEMBL-Plants: tr|I1LGY1|I1LGY1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0416700 16
Haloacid dehalogenase-like hydrolase; TAIR: AT2G38740.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9ZVJ5|SGGP_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp; TrEMBL-Plants: tr|I1LGY1|I1LGY1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0416700 16
Haloacid dehalogenase-like hydrolase; TAIR: AT2G38740.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9ZVJ5|SGGP_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp; TrEMBL-Plants: tr|I1LGY1|I1LGY1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0416700 13
Haloacid dehalogenase-like hydrolase; TAIR: AT2G38740.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9ZVJ5|SGGP_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp; TrEMBL-Plants: tr|I1LGX9|I1LGX9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0416900 15
Haloacid dehalogenase-like hydrolase; TAIR: AT2G38740.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9ZVJ5|SGGP_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp; TrEMBL-Plants: tr|A0A0B2SBW7|A0A0B2SBW7_GLYSO BON1-associated protein 2; Found in the gene: LotjaGi2g1v0416900 13
Haloacid dehalogenase-like hydrolase; TAIR: AT2G38740.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9ZVJ5|SGGP_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp; TrEMBL-Plants: tr|I1LGX8|I1LGX8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0416900 15
Haloacid dehalogenase-like hydrolase; TAIR: AT2G38740.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9ZVJ5|SGGP_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp; TrEMBL-Plants: tr|A0A0B2SBW7|A0A0B2SBW7_GLYSO BON1-associated protein 2; Found in the gene: LotjaGi2g1v0416900 13
Haloacid dehalogenase-like hydrolase superfamily protein; TAIR: AT4G11570.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|P44004|Y488_HAEIN Uncharacterized protein HI_0488; TrEMBL-Plants: tr|A0A1J7GVC4|A0A1J7GVC4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0434200 13
Haloacid dehalogenase-like hydrolase superfamily protein; TAIR: AT4G11570.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|P44004|Y488_HAEIN Uncharacterized protein HI_0488; TrEMBL-Plants: tr|A0A1J7GVC4|A0A1J7GVC4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0434200 13
Enolase-phosphatase E1; TAIR: AT5G53850.2 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|B9N1F9|MTBC_POPTR Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; TrEMBL-Plants: tr|I3SC04|I3SC04_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0153500_LC 12
Enolase-phosphatase E1; TAIR: AT5G53850.2 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|B9N1F9|MTBC_POPTR Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; TrEMBL-Plants: tr|A0A151SVM5|A0A151SVM5_CAJCA Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; Found in the gene: LotjaGi3g1v0153500_LC 16
Enolase-phosphatase E1; TAIR: AT5G53850.2 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|B9N1F9|MTBC_POPTR Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1; TrEMBL-Plants: tr|I3SC04|I3SC04_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0153500_LC 12
Haloacid dehalogenase-like hydrolase; TAIR: AT5G02230.3 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|I1J6W9|I1J6W9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0226500 12
Haloacid dehalogenase-like hydrolase; TAIR: AT5G59480.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|G7IRW0|G7IRW0_MEDTR Haloacid dehalogenase-like hydrolase; Found in the gene: LotjaGi3g1v0284700 12
Riboflavin kinase/fmn hydrolase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|K7M2J5|K7M2J5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0450700 16
Riboflavin kinase/fmn hydrolase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|K7M2J5|K7M2J5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0450700 16
Riboflavin kinase; TAIR: AT4G21470.1 riboflavin kinase/FMN hydrolase; Swiss-Prot: sp|Q84MD8|FHYRK_ARATH Bifunctional riboflavin kinase/FMN phosphatase; TrEMBL-Plants: tr|A0A151S8Q7|A0A151S8Q7_CAJCA Riboflavin kinase; Found in the gene: LotjaGi4g1v0049600 21
Haloacid dehalogenase-like hydrolase; TAIR: AT4G25840.1 glycerol-3-phosphatase 1; Swiss-Prot: sp|F4JTE7|GPP1_ARATH (DL)-glycerol-3-phosphatase 1; TrEMBL-Plants: tr|I3T577|I3T577_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0301000 15
Haloacid dehalogenase-like hydrolase; TAIR: AT5G02230.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|A0A151R7D6|A0A151R7D6_CAJCA Uncharacterized protein C24B11.05; Found in the gene: LotjaGi4g1v0306300 12
Haloacid dehalogenase-like hydrolase; TAIR: AT5G02230.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|A0A151R7D6|A0A151R7D6_CAJCA Uncharacterized protein C24B11.05; Found in the gene: LotjaGi4g1v0306300 12
Haloacid dehalogenase-like hydrolase; TAIR: AT4G39970.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q680K2|GPPL1_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein At4g39970; TrEMBL-Plants: tr|I1KSZ7|I1KSZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0395900 21
Haloacid dehalogenase-like hydrolase superfamily protein; TAIR: AT4G11570.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|P44004|Y488_HAEIN Uncharacterized protein HI_0488; TrEMBL-Plants: tr|A0A1J7GVC4|A0A1J7GVC4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0425800 14
Haloacid dehalogenase-like hydrolase; TAIR: AT2G33255.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q8RYE9|GPPL3_ARATH Haloacid dehalogenase-like hydrolase domain-containing protein At2g33255; TrEMBL-Plants: tr|A0A151T186|A0A151T186_CAJCA Putative uncharacterized hydrolase YOR131C family; Found in the gene: LotjaGi5g1v0162300 21
Haloacid dehalogenase-like hydrolase; TAIR: AT3G62040.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|I3TAQ7|I3TAQ7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0236500 14
Haloacid dehalogenase-like hydrolase; TAIR: AT3G62040.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|I3SRG9|I3SRG9_MEDTR Haloacid dehalogenase-like hydrolase; Found in the gene: LotjaGi5g1v0236500 16
Haloacid dehalogenase-like hydrolase; TAIR: AT3G62040.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|I3TAQ7|I3TAQ7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0236500 14
Haloacid dehalogenase-like hydrolase; TAIR: AT2G32150.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q09893|YAI5_SCHPO Uncharacterized protein C24B11.05; TrEMBL-Plants: tr|A0A0L9U119|A0A0L9U119_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0314700 15
Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT5G44730.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q5E9D6|HDHD3_BOVIN Haloacid dehalogenase-like hydrolase domain-containing protein 3; TrEMBL-Plants: tr|I3TAF4|I3TAF4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0244600 14
Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT5G44730.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q5E9D6|HDHD3_BOVIN Haloacid dehalogenase-like hydrolase domain-containing protein 3; TrEMBL-Plants: tr|I3TAF4|I3TAF4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0244600 14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd16415 CDD 1 1.47