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IPR015875

Source: InterPro

Description

IPR015875 is a IMP dehydrogenase / GMP reductase, conserved site.

<p>Synonym(s): Inosine-5'-monophosphate dehydrogenase, Inosinic acid dehydrogenase; Synonym(s): Guanosine 5'-monophosphate oxidoreductase <p>This entry contains two related enzymes: IMP dehydrogenase and GMP reductase. These enzymes adopt a TIM barrel structure.</p> <p>IMP dehydrogenase ([ec:1.1.1.205]) (IMPDH) catalyses the rate-limiting reaction of<i>de novo</i>GTP biosynthesis, the NAD-dependent reduction of IMP into XMP [[cite:PUB00002466]]. <reaction> Inosine 5-phosphate + NAD<sup>+</sup>+ H<sub>2</sub>O = xanthosine 5-phosphate + NADH </reaction> IMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains. There are two IMP dehydrogenase isozymes in humans [[cite:PUB00002609]]. IMP dehydrogenase nearly always contains a long insertion that has two CBS domains within it.</p> <p>GMP reductase ([ec:1.7.1.7]) catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP [[cite:PUB00000471]]. <reaction> NADPH + guanosine 5-phosphate = NADP<sup>+</sup>+ inosine 5-phosphate + NH<sub>3</sub> </reaction> It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016491
Molecular function Oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj3g3v2769390.1
– PREDICTED: inosine-5'-monophosphate dehydrogenase-like [Cicer arietinum] gi|502107091|ref|XP_004493154.1|
Domains
19
LotjaGi3g1v0440200.1
– Inosine-5'-monophosphate dehydrogenase; TAIR: AT1G16350.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q84XA3|IMDH_VIGUN Inosine-5'-monophosphate dehydrogenase; TrEMBL-Plants: tr|G7KZG9|G7KZG9_MEDTR Inosine-5'-monophosphate dehydrogenase; Found in the gene: LotjaGi3g1v0440200
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd04601 CDD 1 50.00