Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR016527 is a Origin recognition complex subunit 4.
<p>The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded by ORC1-6 [[cite:PUB00052559]]. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle [[cite:PUB00052560]]. ORC directs DNA replication throughout the genome and is required for its initiation [[cite:PUB00052561], [cite:PUB00052562], [cite:PUB00052563]]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [[cite:PUB00052564], [cite:PUB00052565], [cite:PUB00052566], [cite:PUB00102275]]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [[cite:PUB00052567], [cite:PUB00052568], [cite:PUB00052569]]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [[cite:PUB00052560], [cite:PUB00052570], [cite:PUB00052571], [cite:PUB00052572]].</p> <p>In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [[cite:PUB00052561], [cite:PUB00052562], [cite:PUB00052563]]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [[cite:PUB00052563], [cite:PUB00052573], [cite:PUB00052574]].</p> <p>This group represents an origin recognition complex, subunit 4.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Origin recognition complex | A multisubunit complex that is located at the replication origins of a chromosome. | ||
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: origin recognition complex subunit 4-like [Cicer arietinum] gi|502120583|ref|XP_004497011.1| | 12 | ||
| – | Origin recognition complex subunit 4; TAIR: AT2G01120.1 origin recognition complex subunit 4; Swiss-Prot: sp|Q6EWX1|ORC4_ARATH Origin of replication complex subunit 4; TrEMBL-Plants: tr|V7BEU0|V7BEU0_PHAVU Origin recognition complex subunit 4; Found in the gene: LotjaGi5g1v0333300 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00009 | CDD | 1 | 50.00 |