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IPR016574

Source: InterPro

Description

IPR016574 is a Nicalin.

<p>Nicalin is a Nodal signalling antagonist and a distant homologue of the gamma-secretase component Nicastrin [[cite:PUB00054165]]. In humans, Nicalin forms a complex with NOMO (Nodal modulator) and controls the assembly and stability of this complex [[cite:PUB00062803]]. It is a component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes [[cite:PUB00103609], [cite:PUB00097241]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0009966
Biological process Regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.
Subterm of
Regulates
GO:0016020
Cellular component Membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0475000.1
– Nicalin; TAIR: AT3G44330.1 M28 Zn-peptidase nicastrin; Swiss-Prot: sp|Q6NZ07|NCLN_DANRE Nicalin-1; TrEMBL-Plants: tr|A0A151TNY8|A0A151TNY8_CAJCA Nicalin; Found in the gene: LotjaGi3g1v0475000
Domains
20

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03882 CDD 1 100.00