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IPR016651

Source: InterPro

Description

IPR016651 is a Leucine carboxyl methyltransferase 1.

<p>This group represents the Ppm1 (also known as LCMT1) subgroup of leucine carboxymethyltransferases.</p> <p>Ppm1 regulates the activity of serine/threonine phosphatase 2A (PP2A) through methylation of the C-terminal leucine residue of the catalytic subunit of PP2A [[cite:PUB00034741], [cite:PUB00034742], [cite:PUB00034743]]. This affects the heteromultimeric composition of PP2A which in turn affects protein recognition and substrate specificity. Like many other methyltransferases Ppm1 uses S-adenosylmethionine (SAM) as the methyl donor. Ppm1 contains the common SAM-dependent methyltransferase core fold, with various insertions and additions creating a specific PP2A binding site [[cite:PUB00030688]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0495800.1
– Leucine carboxyl methyltransferase; TAIR: AT1G02100.1 Leucine carboxyl methyltransferase; Swiss-Prot: sp|Q8BYR1|TYW4_MOUSE tRNA wybutosine-synthesizing protein 4; TrEMBL-Plants: tr|A0A072U137|A0A072U137_MEDTR Leucine carboxyl methyltransferase; Found in the gene: LotjaGi1g1v0495800
Domains
9
LotjaGi1g1v0495800.2
– Leucine carboxyl methyltransferase; TAIR: AT1G02100.2 Leucine carboxyl methyltransferase; Swiss-Prot: sp|Q8BYR1|TYW4_MOUSE tRNA wybutosine-synthesizing protein 4; TrEMBL-Plants: tr|A0A072U217|A0A072U217_MEDTR Leucine carboxyl methyltransferase; Found in the gene: LotjaGi1g1v0495800
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53335 SUPERFAMILY 1 50.00