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IPR016900 is a Alpha-2-glucosyltransferase Alg10.
<p>Alg10 (asparagine-linked glycosylation) ([ec:2.4.1.256]) is a dolichyl-phosphoglucose-dependent glucosyltransferase which adds the terminal alpha-1,2 glucose to the lipid-linked Glc2Man9GlcNAc2 oligosaccharide. The terminal alpha-1,2-linked glucose residue is important for substrate recognition by the oligosaccharyltransferase [[cite:PUB00019414]]. In Saccharomyces cerevisiae, Alg10 has a role in regulation of the expression of a myo-inositol transporter, Itr1 (hence the name Die2, standing for derepression of Itr1 expression) [[cite:PUB00066987]]. It also regulates the expression of Ino1, which is an inositol-3-phosphate synthase [[cite:PUB00066987]]. Alg10 is homologous to human and rat potassium channel regulatory protein KCR1, which diminishes the cardiac repolarising current I(Kr) drug response [[cite:PUB00043473], [cite:PUB00008706]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Dolichol-linked oligosaccharide biosynthetic process | The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. | ||
| Molecular function | Dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity | Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Alpha-1,2-glucosyltransferase ALG10-A [Medicago truncatula] gi|357505549|ref|XP_003623063.1| | 8 | ||
| – | Alpha-1,2-glucosyltransferase ALG10-A [Medicago truncatula] gi|357505549|ref|XP_003623063.1| | 13 | ||
| – | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; TAIR: AT5G02410.1 DIE2/ALG10 family; Swiss-Prot: sp|Q8L638|ALG10_ARATH Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; TrEMBL-Plants: tr|G7L3H5|G7L3H5_MEDTR Alpha-1,2-glucosyltransferase; Found in the gene: LotjaGi3g1v0224200 | 9 | ||
| – | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; TAIR: AT5G02410.1 DIE2/ALG10 family; Swiss-Prot: sp|Q8L638|ALG10_ARATH Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; TrEMBL-Plants: tr|G7L3H5|G7L3H5_MEDTR Alpha-1,2-glucosyltransferase; Found in the gene: LotjaGi3g1v0224200 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 25.00 |